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GSK2606414

Cat. No. M2734

All AbMole products are for research use only, cannot be used for human consumption.

GSK2606414 Structure
Size Price Availability Quantity
10mM*1mL in DMSO USD 98  USD98 In stock
2mg USD 63  USD63 In stock
5mg USD 99  USD99 In stock
10mg USD 139  USD139 In stock
25mg USD 280  USD280 In stock
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Quality Control & Documentation
Biological Activity

GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed. GSK2606414 (50 and 150 mg/kg, p.o.) inhibits the growth of a human tumor xenograft in mice.

Product Citations
Chemical Information
Molecular Weight 451.44
Formula C24H20F3N5O
CAS Number 1337531-36-8
Solubility (25°C) DMSO 80 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kornlia Szebnyi, et al. Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology

[2] Jiachao Guo, et al. PERK controls bone homeostasis through the regulation of osteoclast differentiation and function

[3] Martin McLaughlin, et al. The PERK Inhibitor GSK2606414 Enhances Reovirus Infection in Head and Neck Squamous Cell Carcinoma via an ATF4-Dependent Mechanism

[4] Mohamed Mahameed, et al. The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors

[5] Xintong Jiang, et al. Effects of GSK2606414 on cell proliferation and endoplasmic reticulum stress‑associated gene expression in retinal pigment epithelial cells

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  Catalog
Abmole Inhibitor Catalog




Keywords: GSK2606414 supplier, PERK, inhibitors, activators

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