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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M9242 | ISRIB | ISRIB is a potent and selective PERK inhibitor with IC50 of 5 nM. |
| M7425 | trans-ISRIB | trans-ISRIB is a integrated stress response (ISR) inhibitor. |
| M2996 | Salubrinal | Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM. |
| M2735 | GSK2656157 | GSK2656157 is an ATP-competitive and highly selective inhibitor of PERK with IC50 of 0.9 nM, 500-fold greater against a panel of 300 kinases. |
| M2734 | GSK2606414 | GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed. |
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