PERK Protein kinase R (PKR)-like endoplasmic reticulum kinase

Inhibitors

Cat.No.	Name	Information
M20356	WAY-354896	WAY-354896 is a Dual activator of Protein Kinase R (PKR) and Protein Kinase R-Like Kinase (PERK).
M13716	CCT020312	CCT020312 is a selective EIF2AK3/PERK activator. CCT020312 elicits EIF2A phosphorylation in cells.
M9242	ISRIB	ISRIB is a potent and selective PERK inhibitor with IC50 of 5 nM.
M7425	trans-ISRIB	trans-ISRIB is a integrated stress response (ISR) inhibitor.
M2996	Salubrinal	Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM.
M2735	GSK2656157	GSK2656157 is an ATP-competitive and highly selective inhibitor of PERK with IC50 of 0.9 nM, 500-fold greater against a panel of 300 kinases.
M2734	GSK2606414	GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed.