Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM.
|Solubility (25°C)||DMSO 76 mg/mL|
|Storage||2-8°C, protect from light|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Enrique Font-Belmonte, et al. J Neurochem. Post-ischemic salubrinal administration reduces necroptosis in a rat model of global cerebral ischemia
 Daquan Liu, et al. Sci Rep. eIF2α signaling regulates ischemic osteonecrosis through endoplasmic reticulum stress
 Y Liu, et al. Zhonghua Xin Xue Guan Bing Za Zhi. Salubrinal improves cardiac function in rats with heart failure post myocardial infarction through reducing endoplasmic reticulum stress-associated apoptosis
 Rui-Jun Li, et al. Mol Med Rep. Salubrinal protects cardiomyocytes against apoptosis in a rat myocardial infarction model via suppressing the dephosphorylation of eukaryotic translation initiation factor 2α
 Emanuela Colla, et al. J Neurosci. Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo
 Anna-Leena Sokka, et al. J Neurosci. Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain
 Michael Boyce, et al. Science. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress
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