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Salubrinal

Cat. No. M2996
Salubrinal Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
2mg USD 40  USD40 In stock
5mg USD 63  USD63 In stock
10mg USD 95  USD95 In stock
25mg USD 190  USD190 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 479.81
Formula C21H17Cl3N4OS
CAS Number 405060-95-9
Purity >99%
Solubility DMSO 76 mg/mL
Storage 2-8°C, protect from light
References

[1] Enrique Font-Belmonte, et al. J Neurochem. Post-ischemic salubrinal administration reduces necroptosis in a rat model of global cerebral ischemia

[2] Daquan Liu, et al. Sci Rep. eIF2α signaling regulates ischemic osteonecrosis through endoplasmic reticulum stress

[3] Y Liu, et al. Zhonghua Xin Xue Guan Bing Za Zhi. Salubrinal improves cardiac function in rats with heart failure post myocardial infarction through reducing endoplasmic reticulum stress-associated apoptosis

[4] Rui-Jun Li, et al. Mol Med Rep. Salubrinal protects cardiomyocytes against apoptosis in a rat myocardial infarction model via suppressing the dephosphorylation of eukaryotic translation initiation factor 2α

[5] Emanuela Colla, et al. J Neurosci. Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo

[6] Anna-Leena Sokka, et al. J Neurosci. Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain

[7] Michael Boyce, et al. Science. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

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