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Cat. No. M9242
ISRIB Structure
Size Price Availability Quantity
5mg USD 70  USD70 In stock
10mg USD 130  USD130 In stock
25mg USD 260  USD260 In stock
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Quality Control & Documentation
Biological Activity

ISRIB is a potent and selective PERK inhibitor with IC50 of 5 nM. ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly.

Chemical Information
Molecular Weight 451.34
Formula C22H24Cl2N2O4
CAS Number 548470-11-7
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Sidrauski C, et al. Elife. The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly.

[2] Sidrauski C, et al. Elife. Pharmacological brake-release of mRNA translation enhances cognitive memory.

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trans-ISRIB is a integrated stress response (ISR) inhibitor.


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Abmole Inhibitor Catalog

Keywords: ISRIB supplier, PERK, inhibitors, activators

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