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Rineterkib hydrochloride (compound B) is an orally active inhibitor of ERK1/2 that exerts an antiproliferative effect by activating mutations in the MAPK pathway. Rineterkib hydrochloride can also inhibit RAF. This activity is particularly associated with KRAS-mutant non-small cell lung cancer, BRAF-mutant non-small cell lung cancer, KRAS-mutant pancreatic cancer, KRAS-mutant colon cancer, and KRAS mutant ovarian cancer.
| Molecular Weight | 614.89 |
| Formula | C26H28BrClF3N5O2 |
| CAS Number | 1715025-34-5 |
| Solubility (25°C) | DMSO ≥ 200 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
[3] No authors listed. Carteolol
[4] S HIFT, et al. Wien Med Wochenschr. [Prothipendyl-hydrochloride, a new neuroleptic]
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