Certificate of Analysis
| Product Name: | Rineterkib hydrochloride |
| Catalog Number: | M10880 |
| CAS Number: | 1715025-34-5 |
Physical and Chemical Properties
| Formula: | C26H28BrClF3N5O2 |
| Molecular Weight: | 614.89 |
| Solubility: | DMSO ≥ 200 mg/mL |
| Storage: | 4°C, protect from light, dry, sealed |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >99% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Rineterkib hydrochloride (compound B) is an orally active inhibitor of ERK1/2 that exerts an antiproliferative effect by activating mutations in the MAPK pathway. This activity is particularly associated with KRAS-mutant non-small cell lung cancer, BRAF-mutant non-small cell lung cancer, KRAS-mutant pancreatic cancer, KRAS-mutant colon cancer, and KRAS mutant ovarian cancer. Rineterkib hydrochloride can also inhibit RAF. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |