All AbMole products are for research use only, cannot be used for human consumption.
Rineterkib (compound B) is an orally active inhibitor of ERK1/2 that exerts an antiproliferative effect by activating mutations in the MAPK pathway. This activity is particularly associated with KRAS-mutant non-small cell lung cancer, BRAF-mutant non-small cell lung cancer, KRAS-mutant pancreatic cancer, KRAS-mutant colon cancer, and KRAS-mutant ovarian cancer. Rineterkib hydrochloride can also inhibit RAF.
| Molecular Weight | 578.42 |
| Formula | C26H27BrF3N5O2 |
| CAS Number | 1715025-32-3 |
| Solubility (25°C) | DMSO ≥ 150 mg/mL |
| Storage | 4°C, protect from light, dry |
| Related ERK Products |
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PACAP-38 (31-38), human, mouse, rat is a PAC1 receptor activator and increases the α-secretase activity. |
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Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent. |
| ZINC12409120
ZINC12409120 is a high selective ERK inhibitor. |
| Tizaterkib (hexanedioic acid)
Tizaterkib hexanedioic acid is a potent and selective ERK2 inhibitor, with an IC50 of 0.6 nM. |
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