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ERK1/2 inhibitor 9

Cat. No. M42119
ERK1/2 inhibitor 9 Structure
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Biological Activity

ERK1/2 inhibitor 9 (Probe 1) is a covalent ERK1/2 inhibitor.

Chemical Information
Molecular Weight 586.08
Formula C31H32ClN7O3
CAS Number 2169302-75-2
Form Solid
Storage -20°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shunsuke Yamakita et al. Mol Pain. Synergistic activation of ERK1/2 between A-fiber neurons and glial cells in the DRG contributes to pain hypersensitivity after tissue injury

[2] Gopinathan Pillai Sreekanth et al. Antiviral Res. JNK1/2 inhibitor reduces dengue virus-induced liver injury

[3] Huilong Chen et al. Int J Clin Exp Pathol. CXCR4 inhibitor attenuates allergen-induced lung inflammation by down-regulating MMP-9 and ERK1/2

[4] Eo-Jin Lee et al. Oncol Rep. IL-5-induced migration via ERK1/2-mediated MMP-9 expression by inducing activation of NF-κB in HT1376 cells

[5] K Lee et al. Cell Signal. cAMP potentiates H(2)O(2)-induced ERK1/2 phosphorylation without the requirement for MEK1/2 phosphorylation

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Keywords: ERK1/2 inhibitor 9 supplier, ERK, inhibitors, activators

 
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