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BAY-876 is a potent, highly selective, cell-permeable inhibitor of glucose transporter GLUT1. It had an IC50 value of 2 nM in vitro and inhibited glucose uptake by Hela-MaTu cells with an IC50 value of 3.2 nM. BAY-876 was at least 130-fold selective for GLUT1 relative to GLUT2, GLUT3, GLUT4 and a panel of 18 kinases and 68 proteins. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis.
| Molecular Weight | 496.42 |
| Formula | C24H16F4N6O2 |
| CAS Number | 1799753-84-6 |
| Solubility (25°C) | DMSO 80 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Qin Wu, et al. GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer
| Related GLUT Products |
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