Neutrophil gelatinase-associated lipocalin (LCN2) is a secreted protein that belongs to the kallikrein superfamily. This protein is released from injured renal tubular cells after various destructive stimuli and has been described by nephrologists as one of the most promising biomarkers of afferent acute kidney injury (AKI). Recent evidence also suggests its role as a biomarker in various other renal and non-renal diseases. In addition, recent studies seem to indicate that this factor may also be involved in the development and progression of chronic kidney disease.NGAL is the first known mammalian protein that specifically binds organic molecules called glycosides, which are high-affinity iron chelators.NGAL was first known as an antimicrobial factor of natural immunity and an acute phase protein, and is currently one of the most interesting and enigmatic proteins. As an intracellular iron carrier and protector of MMP9 from proteolysis, NGAL has a significant pro-tumor effect and has been observed in different human tumors (e.g. breast, stomach, esophagus, brain). In thyroid cancer, NGAL is strongly induced by NF-kB, an important factor involved in the link between tumor growth and chronic inflammation and tumor development. Thus, Lipocalin-2 (LCN2/NGAL) has been implicated in various processes, including cell differentiation, proliferation, survival, and morphogenesis.
Endotoxin <1 EU/µg
Molecular weight: 21.8 KDa
Supplied as a 0.2 μm filtered solution of PBS, 50% Glycerol, pH 7.4.
The product is shipped on dry ice/polar packs.
Upon receipt, store it immediately at the temperature listed below.
| Form | Solution |
| Solubility (25°C) | You can dilute the product with Sterile PBS solution |
| Storage | Store at ≤ -70°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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