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Abatacept

Cat. No. M11481

All AbMole products are for research use only, cannot be used for human consumption.

Abatacept Structure
Synonym:

Orencia;CTLA4lg;BMS-188667

Size Price Availability
1mg USD 550  USD550 3-4 Weeks
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Quality Control & Documentation
Biological Activity

Abatacept is a soluble fusion protein consisting of the extra-cellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1. Abatacept binds to antigen presenting cells CD80 and CD86, blocks costimulatory signals and inhibits T cell activation, and is used in the study of rheumatoid arthritis and juvenile rheumatoid arthritis.

Chemical Information
CAS Number 332348-12-6
Form Solid
Storage 4°C, protect from light, do not freeze.
References

[1] Benjamin Watkins, et al. J Clin Oncol. Phase II Trial of Costimulation Blockade With Abatacept for Prevention of Acute GVHD

[2] Andrea Rubbert-Roth, et al. N Engl J Med. Trial of Upadacitinib or Abatacept in Rheumatoid Arthritis

[3] Ayca Kiykim, et al. J Allergy Clin Immunol Pract. Abatacept as a Long-Term Targeted Therapy for LRBA Deficiency

[4] Manuel Pombo-Suarez, et al. Expert Rev Clin Immunol. Abatacept for the treatment of rheumatoid arthritis

[5] Hannah A Blair, et al. Drugs. Abatacept: A Review in Rheumatoid Arthritis

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Keywords: Abatacept, Orencia;CTLA4lg;BMS-188667 supplier, Immunology/Inflammation, inhibitors, activators

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