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Abatacept

Cat. No. M11481
Abatacept Structure
Synonym:

Orencia;CTLA4lg;BMS-188667

Size Price Availability
5mg USD 900  USD900 Out of stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Abatacept is a CTLA-4 agonist that binds to antigen presenting cells CD80 and CD86, blocks costimulatory signals and inhibits T cell activation, and is used in the study of rheumatoid arthritis and juvenile rheumatoid arthritis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number 332348-12-6
Purity >99%
Solubility N/A
Storage 4°C , protect from light
References

[1] Benjamin Watkins, et al. J Clin Oncol. Phase II Trial of Costimulation Blockade With Abatacept for Prevention of Acute GVHD

[2] Andrea Rubbert-Roth, et al. N Engl J Med. Trial of Upadacitinib or Abatacept in Rheumatoid Arthritis

[3] Ayca Kiykim, et al. J Allergy Clin Immunol Pract. Abatacept as a Long-Term Targeted Therapy for LRBA Deficiency

[4] Manuel Pombo-Suarez, et al. Expert Rev Clin Immunol. Abatacept for the treatment of rheumatoid arthritis

[5] Hannah A Blair, et al. Drugs. Abatacept: A Review in Rheumatoid Arthritis

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Keywords: Abatacept, Orencia;CTLA4lg;BMS-188667 supplier, inhibitors

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