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Sotatercept

Cat. No. M24529

All AbMole products are for research use only, cannot be used for human consumption.

Sotatercept Structure
Synonym:

ACE-011; MK-7962

Size Price Availability Quantity
1mg USD 700  USD700 In stock
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Quality Control & Documentation
Biological Activity

Sotatercept (ACE-011; MK-7962) is a first-in-class activin receptor 2A (ACVR2A) type IgG Fc fusion protein. Sotatercept combines activin and growth differentiation factor to try to restore the balance between growth promotion and growth inhibition signal pathways. Sotatercept has potential application in pulmonary arterial hypertension, anemia, bone loss, erythropoiesis, multiple myeloma (MM) osteolytic lesions.

Chemical Information
CAS Number 1001080-50-7
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Marius M Hoeper, et al. N Engl J Med. Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension

[2] Marc Humbert, et al. Eur Respir J. Sotatercept for the treatment of pulmonary arterial hypertension: PULSAR open-label extension

[3] Sachindra R Joshi, et al. Sci Rep. Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension

[4] Peiran Yang, et al. N Engl J Med. Sotatercept for Pulmonary Arterial Hypertension

[5] Marc Humbert, et al. N Engl J Med. Sotatercept for the Treatment of Pulmonary Arterial Hypertension

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Keywords: Sotatercept, ACE-011; MK-7962 supplier, Fusion Proteins, inhibitors, activators

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