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Sotatercept

Cat. No. M24529
Sotatercept Structure
Synonym:

ACE-011; MK-7962

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Quality Control & Documentation
Biological Activity

Sotatercept (ACE-011) is a soluble activin receptor 2A (ACVR2A) type IgG Fc fusion protein. Sotatercept combines activin and growth differentiation factor to try to restore the balance between growth promotion and growth inhibition signal pathways. Sotatercept has potential application in pulmonary arterial hypertension, anemia, bone loss, erythropoiesis, multiple myeloma (MM) osteolytic lesions.

Chemical Information
CAS Number 1001080-50-7
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Marius M Hoeper, et al. N Engl J Med. Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension

[2] Marc Humbert, et al. Eur Respir J. Sotatercept for the treatment of pulmonary arterial hypertension: PULSAR open-label extension

[3] Sachindra R Joshi, et al. Sci Rep. Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension

[4] Peiran Yang, et al. N Engl J Med. Sotatercept for Pulmonary Arterial Hypertension

[5] Marc Humbert, et al. N Engl J Med. Sotatercept for the Treatment of Pulmonary Arterial Hypertension

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Keywords: Sotatercept, ACE-011; MK-7962 supplier, TGF-beta/Smad, inhibitors, activators


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