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 About 16 results found for searched term "ML-SI3" (0.038 seconds)

Cat.No.  Name Information
M1828 Tandutinib Tandutinib (MLN518), previously known as CT53518, is an orally active multitargeted tyrosine kinase inhibitor of FLT3, PDGFR and c-Kit.
M2122 MLN9708 MLN9708 is a novel orally bioactive proteasome inhibitor, inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC50 value of 3.4 nM.
M2285 MLN2238 MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM, respectively.
M5047 ML216 ML216 is a potent inhibitor of the DNA unwinding activity of BLM helicase; showing similar IC50s of 3.0 and 0.97 μM for full length BLM and BLM636–1298 respectively.
M8912 ML-18 ML18 is Bombesin receptor subtype 3 (BRS-3) antagonist (IC50 = 4.8 μM).
M10782 APG-1387 APG-1387 is a divalent SMAC mimetic that is an IAP antagonist that blocks the activity of the IAP family of proteins (XIAP, cIAP-1, cIAP-2, and ML-IAP). APG-1387 induces degradation of cIAP-1 and XIAP proteins as well as caspase-3 activation and PARP lysis, leading to apoptosis. APG-1387 can be used for the study of hepatocellular carcinoma, ovarian cancer and nasopharyngeal carcinoma.
M11489 Recombinant Human MCP-1/CCL2(E. coli) The EC50 value of human MCP-1/CCL2 on Ca2+ mobilization assay in CHO-K1/Gα15/hCCR2 cells (human Gα15 and human CCR2 stably expressed in CHO-K1 cells) is less than 1.0 μg/ml. Accession # : P13500.
M11492 Recombinant Human Endostatin (P. pastoris) Recombinant human Endostatin protein (P. pastoris) is determined by the formation of endothelial cells. Endostatin concentration of 10 μg/ mL showed obvious anti-angiogenesis effect. Protein structure: Endostatin (ALA1571-Lys1754), Accession # P39060.
M11493 Recombinant Human SCF (P. pastoris) The recombinant human SCF protein stimulated TF-1 cells dose-dependent, ED50 < 2.0 ng/ mL, and corresponding specific activity was 5 × 10< SUP > 5IU/mg. Protein structure: Coexpressed with n-terminal methionine. Accession # : P21583-1.
M11495 Recombinant Human TNF-α (E. coli) Recombinant human TNF-α protein (E. coli) is a homotrimer with a subunit molecular mass of 17.3 kDa. TNF-a plays a major role in growth regulation, differentiation, inflammation, viral replication, tumorigenesis, and autoimmune diseases; and in viral, bacterial, fungal, and parasitic infections. ED50 < 30.0 pg/ml, measured in a cytotoxicity assay using L-929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D, corresponding to a specific activity of > 3.3 × 107 units/mg.
M19998 Recombinant Mouse IL-2 (E. coli) Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine CTLL-2 cells is less than 0.2 ng/ml, corresponding to a specific activity of > 5.0 × 106 IU/mg.Accession # P04351.
M20398 Ixazomib Citrate (MLN9708) Ixazomib Citrate (MLN9708) immediately hydrolyzed to MLN2238, the biologically active form, on exposure to aqueous solutions or plasma. MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50/Ki of 3.4 nM/0.93 nM in cell-free assays, less potent to β1 and little activity to β2. Phase 3.
M20832 ML-SI3 ML-SI3 is a potent TRPML channel inhibitor with IC50s of 4.7 µM and 1.7 µM for TRPML1 and TRPML2, respectively.
M21096 TXA6101 TXA6101 is a filamentous temperature-sensitive mutant Z (FtsZ) protein inhibitor. TXA6101 has an antibacterial activity MIC value of 1 μg/mL against MRSA isolates expressing either G193D or G196S mutant FtsZ, retaining significant activity against the TXA707-resistant FtsZ mutant. It is being developed for use against Gram-negative bacteria.
M21463 Recombinant Human HB-EGF (E. coli) HB-EGF signals through the EGF receptor to stimulate the proliferation of smooth muscle cells, epithelial cells and keratinocytes. ED50 < 0.75 ng/ml, measured in a cell proliferation assay using 3T3 cells.

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