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APG-1387

Cat. No. M10782

All AbMole products are for research use only, cannot be used for human consumption.

APG-1387 Structure

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Biological Activity

APG-1387 is a divalent SMAC mimetic that is an IAP antagonist that blocks the activity of the IAP family of proteins (XIAP, cIAP-1, cIAP-2, and ML-IAP). APG-1387 induces degradation of cIAP-1 and XIAP proteins as well as caspase-3 activation and PARP lysis, leading to apoptosis. APG-1387 can be used for the study of hepatocellular carcinoma, ovarian cancer and nasopharyngeal carcinoma.

Chemical Information
Molecular Weight 1157.4
Formula C60H72N10O10S2
CAS Number 1570231-89-8
Solubility (25°C) DMSO ≥ 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Zide Chen, et al. Front Pharmacol. The SMAC Mimetic APG-1387 Sensitizes Immune-Mediated Cell Apoptosis in Hepatocellular Carcinoma

[2] Bao-Xia Li, et al. J Exp Clin Cancer Res. Correction to: Novel smac mimetic APG-1387 elicits ovarian cancer cell killing through TNF-alpha, Ripoptosome and autophagy mediated cell death pathway

[3] Wentao Pan, et al. Biochem Pharmacol. A novel SMAC mimetic APG-1387 exhibits dual antitumor effect on HBV-positive hepatocellular carcinoma with high expression of cIAP2 by inducing apoptosis and enhancing innate anti-tumor immunity

[4] Bao-Xia Li, et al. J Exp Clin Cancer Res. Novel smac mimetic APG-1387 elicits ovarian cancer cell killing through TNF-alpha, Ripoptosome and autophagy mediated cell death pathway

[5] Ning Li, et al. Cancer Lett. A novel Smac mimetic APG-1387 demonstrates potent antitumor activity in nasopharyngeal carcinoma cells by inducing apoptosis

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Keywords: APG-1387 supplier, IAP, inhibitors, activators

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