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ML418 

Cat. No. M29031

All AbMole products are for research use only, cannot be used for human consumption.

ML418  Structure

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Quality Control & Documentation
Biological Activity

ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker. ML418 inhibits Kir7.1 with an IC50 value of 0.31 μM. ML418 can be used for the research of neurological, cardiovascular, endocrine and muscle disorders.

Chemical Information
Molecular Weight 377.87
Formula C19H24ClN3O3
CAS Number 1928763-08-9
Form Solid
Solubility (25°C) DMSO 20.83 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] You-You Lv, et al. CNS Neurosci Ther. SUMOylation of Kir7.1 participates in neuropathic pain through regulating its membrane expression in spinal cord neurons

[2] C David Weaver, et al. Am J Physiol Cell Physiol. Next-generation inward rectifier potassium channel modulators: discovery and molecular pharmacology

[3] David Ermert, et al. Mol Immunol. The hijackers guide to escaping complement: Lessons learned from pathogens

[4] Sujay V Kharade, et al. Mol Pharmacol. Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590

[5] Daniel R Swale, et al. ACS Chem Neurosci. ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels

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  Catalog
Abmole Inhibitor Catalog




Keywords: ML418  supplier, Potassium Channel, inhibitors, activators

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