About 30 results found for searched term "MI-2" (0.006 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1760 | Palomid 529 | mTOR |
| P529 | ||
| Palomid 529 (P529) is a novel potent PI3K/Akt/mTOR inhibitor and shows a potent antiproliferative activity in the NCI-60 cell lines panel, with growth inhibitory 50 (GI50) <35 μM. | ||
| M1762 | Luminespib (AUY922) | HSP |
| NVP-AUY922; Luminespib | ||
| Luminespib (AUY922) is a small molecule Heat Shock Protein 90 (HSP90) inhibitor with IC50 values of 13 and 21 nM for HSP90α and HSP90β respectively. | ||
| M1763 | Mirdametinib (PD0325901) | MEK |
| Mirdametinib；PD325901 | ||
| Mirdametinib (PD0325901) is a highly potent and selective MEK inhibitor with an IC50 in C26 cells of 0.33nM. | ||
| M2007 | Romidepsin (FK228) | HDAC |
| FK228; ISTODAX; Depsipeptide; FR 901228; NSC 630176 | ||
| Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a structurally unique, potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M2155 | (1S-cis)-Milnacipran Hydrochloride | 5-HT Receptor |
| Levomilnacipran hydrochloride; F-2695 hydrochloride | ||
| (1S-cis)-Milnacipran hydrochloride is a selective norepinephrine and serotonin reuptake inhibitor approved for the management of fibromyalgia. | ||
| M2278 | Bosentan Hydrate | Endothelin Receptor |
| Benzenesulfonamide Hydrate; Ro-47-0203 Hydrate | ||
| Bosentan is an endothelin (ET) receptors antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. | ||
| M2387 | Aminothiazole | Antibiotic |
| 2-Aminothiazole; 2-Thiazolylamine | ||
| Aminothiazole can be used as a thyroid inhibitor and it has antibacterial activity. | ||
| M2467 | Bosentan | Endothelin Receptor |
| Benzenesulfonamide; Ro-47-0203 | ||
| Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. | ||
| M2548 | Cysteamine hydrochloride | Animal Modeling |
| β-MEA Hydrochloride; β-Mercaptoethylamine Hydrochloride; 2-Aminoethanethiol Hydrochloride | ||
| Cysteamine HCl, the hydrochloride form of Cysteamine, is also a transglutaminase 2 (TGM2) inhibitor, which can be used to induce gastrointestinal disorders in a mouse model as well as a duodenal ulcer model. In addition, Cysteamine HCl has the ability to modulate the activity of dopamine neurons in the striatum of awake, freely moving rats by inhibiting the increased dopamine release from amphetamine, and has antioxidant activity. | ||
| M2712 | Fosaprepitant dimeglumine salt | Neurokinin Receptor |
| MK-0517 dimeglumine salt; L-758,298 dimeglumine salt | ||
| Fosaprepitant is a water-soluble phosphoryl procompound for Aprepitant which is a NK1 antagonist.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M55629 | MIPS-21335 | PI3K |
| MIPS21335 | ||
| MIPS-21335 is a PI3KC2α inhibitor, with IC50 of 7 nM. MIPS-21335 also inhibits PI3KC2β, p110α, p110β and p110δ with IC50 values of 0.043, 0.140, 0.386, 0.742 μM, respectively. | ||
| M2995 | Salinosporamide A | Proteasome |
| (-)-Salinosporamide A; ML 858; NPI 0052; Marizomib | ||
| Salinosporamide A (NPI-0052, Marizomib) is a novel marine derived proteasome inhibitor which inhibits CT-L, C-L, and T-L proteasome activities in human erythrocyte-derived 20S proteasomes with EC50 of 3.5 nM, 430 nM, 28 nM. | ||
| M3046 | Tacrine hydrochloride | AChR/AChE |
| Hydroaminacrine; NSC72108 HCl | ||
| Tacrine is a centrally acting anticholinesterase and indirect cholinergic agonist. | ||
| M3238 | 4-Quinazolinamine | EGFR/HER2 |
| 4-Aminoquinazoline, NSC 288012 | ||
| 4-Quinazolinamine (4-Aminoquinazoline) is a potent and highly selective EGFR tyrosine kinase inhibitor. | ||
| M3258 | Thioguanine | DNA/RNA Synthesis |
| 6-Thioguanine; 6-TG; 2-Amino-6-mercaptopurine; 2-Amino-6-purinethiol | ||
| Thioguanine is a purine antimetabolite widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients. | ||
| M3357 | Telbivudine | Anti-infection |
| Epavudine; L-Thymidine; NV 02B | ||
| Telbivudine (Epavudine) is an orally active, potent antiviral inhibitor of hepatitis B virus (HBV) replication. Telbivudine is an antiviral compound used in hepatitis B research. | ||
| M3379 | Trifluridine | DNA/RNA Synthesis |
| Trifluridine; FTD; 5-Trifluorothymidine; NSC 529182; NSC 75520 | ||
| Trifluridine (Trifluorothymidine) is an irreversible and orally active thymidylate synthase inhibitor, and thereby suppressing DNA synthesis. Trifluridine is an antiviral molecule used for research of HSV, rhabdovirus and orthopoxvirus infection. | ||
| M3586 | Pramipexole dihydrochloride Monohydrate | Dopamine Receptor |
| Pramipexole 2HCL monohydrate | ||
| Pramipexole dihydrochloride Monohydrate is a partial/full D2S, D2L, D3, D4, receptor agonist with a Ki of 3.9, 2.2, 0.5, 5.1 nM. | ||
| M3639 | MALT1 inhibitor (MI-2) | MALT1 |
| ABM-3912; MI-2 | ||
| MALT1 inhibitor is an irreversible MALT1 inhibitor with IC50 of 5.84 μM. | ||
| M4254 | (+)Gomisin-M2 | Others |
| CAS# 100759-78-2 | ||
| (+)Gomisin-M2 | ||
| M4304 | Ergosterol | Ferroptosis |
| Ergosterin; Provitamin D; Provitamin D2 | ||
| Ergosterol is a major sterol in fungi with antioxidant, antiproliferative and anti-inflammatory activities and inhibits iron death. | ||
| M4817 | Tacalcitol | Vitamin |
| 1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3 | ||
| Tacalcitol is a synthetic vitamin D3 analog. | ||
| M4907 | Doxycycline Hyclate | MMP |
| Doxycycline hydrochloride hemiethanolate hemihydrate; WC2031 | ||
| Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. | ||
| M4972 | 3-Amino-5-mercapto-1,2,4-triazole | Plant growth regulators |
| Amitrole (3-amino-1,2,4-triazole) is a widely used herbicide. | ||
| M4991 | Dihydroartemisinin | Parasite |
| β-Dihydroartemisinin; DHA; Artenimol; CAS# 81496-82-4 | ||
| Dihydroartemisinin is a potent anti-malaria agent. Dihydroartemisinin, a derivative of artemisinin in which the C-10 lactone group is replaced by hemiacetals and active metabolites of all artemisinin compounds, is a widely used antimalarial compound that effectively induces iron death in acute myeloid leukemia cells (HL60, KG1, and THP-1) by regulating iron metabolism. | ||
| M5046 | Imidafenacin (ONO-8025) | AChR/AChE |
| KRP-197; ONO-8025 | ||
| Imidafenacin (ONO-8025) is a urinary antispasmodic of the anticholinergic class.Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors (IC50=4.13 nM). | ||
| M5106 | DAPI dihydrochloride | Fluorescent Dye |
| 4',6-Diamidino-2-phenylindole dihydrochloride | ||
| DAPI dihydrochloride is A fluorescent dye that binds DNA rich in a-T sequences. The maximum excitation/emission wavelength is 358nm/461 nm, and the blue fluorescence is often used to observe the nucleus and nucleic acid. Store at room temperature away from light. | ||
| M5231 | GSK2269557 | PI3K |
| Nemiralisib; GSK-2269557 | ||
| Nemiralisib, also known as GSK-2269557, is a potent and selective PI3Kδ inhibitor(pKi = 9.9). | ||
| M5360 | 2-Aminoheptane | Others |
| Tuaminoheptanez, Tuamine, Heptamine, 1-Methylhexylamine, 2-Heptylamine | ||
| 2-Aminoheptane is a nasal decongestant drug which is a sympathomimetic stimulant and vasoconstrictor. | ||
| M5380 | Aceglutamide | Autophagy |
| α-N-Acetyl-L-glutamine, N2-Acetylglutamine | ||
| Aceglutamide is a precursor compound to glutamine that improves nerve cell metabolism. | ||
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