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Telbivudine

Cat. No. M3357
Telbivudine Structure
Synonym:

Epavudine; L-Thymidine; NV 02B

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 37  USD37 In stock
10mg USD 65  USD65 In stock
50mg USD 195  USD195 In stock
100mg USD 270  USD270 In stock
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Quality Control & Documentation
Biological Activity

Telbivudine is an antiviral compound used in hepatitis B research.

Product Citations
Chemical Information
Molecular Weight 242.23
Formula C10H14N2O5
CAS Number 3424-98-4
Solubility (25°C) DMSO 45 mg/mL
Water 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] No authors listed. Telbivudine

[2] David Yiu-Kuen But, et al. Safety evaluation of telbivudine

[3] Kathryn Nash. Telbivudine in the treatment of chronic hepatitis B

[4] Susan J Keam. Telbivudine

[5] Jules Dienstag, et al. Telbivudine

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Keywords: Telbivudine, Epavudine; L-Thymidine; NV 02B supplier, Anti-infection, inhibitors, activators

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