About 32 results found for searched term "LyP-2" (0.093 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3825 | Pluronic F-127 | Cell Staining |
| Poloxamer 407; Polyethylene-polypropylene glycol; PF-127 | ||
| Pluronic F-127 was used for fluorescent labeling of blood vessels, astrocytes, and neurons. Pluronic F-127 is frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, etc. to improve their water solubility. | ||
| M51506 | LyP-2 | Others |
| LyP-2 is a peptide that homes to tumor lymphatics. | ||
| M2071 | ONX-0914 | Proteasome |
| PR-957 | ||
| Onx-0914 (PR-957) is a selective inhibitor of low molecular weight polypeptide 7 (LMP7), a chymotrypsin subunit of the immune proteasome. Onx-0914 blocks cytokine production and reduces the progression of experimental arthritis. Onx-0914 is a non-competitive irreversible inhibitor of mycobacterium proteasome (Ki=5.2 μM). Onx-0914 activates latent HIV-1 through HF-1-mediated p-TEFb activation. | ||
| M25536 | Recombinant Human CXCL13/BCA-1 (E. coli) | Cytokines and Growth Factors |
| CXC chemokine BLC; Small-inducible cytokine B13 | ||
| CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. Recombinant human CXCL13 is a single non-glycosylated polypeptide chain containing 87 amino acids and mature human BCA-1 shares 64 % amino acid sequence similarity with the murine protein and 23–34 % amino acid sequence identity with other known CXC chemokines. Determined by a chemotaxis bioassay using human B cells, the biological activity is in a concentration range of 1.0-10 ng/ml. | ||
| M4003 | Isoquercitrin | Wnt/beta-catenin |
| Quercetin 3-glucoside; IQ | ||
| Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway. Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. | ||
| M4062 | Punicalagin | Anti-infection |
| Punicalagin is a species from Punica Granatum L. Or polyphenols isolated from the leaves of Terminalia catappa L. Punicalagin is a reversible, noncompetitive 3CLpro inhibitor that inhibits SARS-COV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) drug with antioxidant, anti-inflammatory and anticancer effects. Punicalagin has the potential to be used in COVID-19 research. | ||
| M4179 | Neochlorogenic-acid | NF-κB |
| trans-5-O-Caffeoylquinic acid | ||
| Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid can inhibit the production of TNF-α and IL-1β. Neochlorogenic acid inhibited the expression of iNOS and COX-2 proteins. Neochlorogenic acid also inhibited the activation of phosphorylated NF-κB P65 and P38 MAPK. | ||
| M4208 | (-)-Epigallocatechin gallate | EGFR/HER2 |
| EGCG; Epigallocatechol Gallate | ||
| (-)-Epigallocatechin Gallate is an antioxidant polyphenol flavonoid form green tea, and inhibits the activation of EGFR, HER2 and HER3, with antitumor activity. | ||
| M4361 | Polyphyllin-I | JNK |
| Polyphyllin I is a bioactive ingredient extracted from Paris Polyphylla with strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis. | ||
| M4363 | Polyphyllin-VI | Pyroptosis |
| Polyphyllin VI, an active saponin, has anticancer activity. Polyphyllin VI induces G2/M cell cycle arrest and induces apoptosis. Polyphyllin VI induces caspase-1-mediated pyroptosis by inducing ROS/NF-κB/NLRP3/GSDMD signaling axis in non-small cell lung cancer. | ||
| M4519 | Procyanidin-B1 | TLR |
| Procyanidin B1 is a polyphenolic flavonoid that exists in common fruits and can bind to TLR4/MD-2 complex, showing anti-inflammatory activity. | ||
| M4599 | Arbutin | Others |
| p-Arbutin; β-Arbutin | ||
| Arbutin (β -arbutin) is a natural polyphenol isolated from the bear fruit plant Arctostaphylos uvaursi with antioxidant, anti-inflammatory and anti-tumor properties. It is a competitive inhibitor of tyrosinase in melanocytes, with a Kiapp value of 1.42 mM for monopholase. The value of p-diphenol enzyme Kiapp was 0.9 mM. Arbutin is also used as a bleaching agent. | ||
| M6979 | ML348 | Phospholipase |
| GNF-Pf-1127; ML-348 | ||
| ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor with an IC50 of 210 nM. | ||
| M6980 | ML 349 | Others |
| ML 349 is a selective and reversible lysophospholipase 2 (LYPLA2) inhibitor. | ||
| M8552 | Allyphenyline oxalate | Others |
| Allyphenyline is a potent α2C-adrenoceptor/serotoni |
||
| M10102 | Calcitonin | Peptides |
| calcitar; calcitrin; SALMON | ||
| Calcitonin is a single-chain polypeptide composed of 32 amino acid residues, the major physiological effects of calcitonin are inhibition of bone resorption and deposition of postabsorptive calcium into bone following a meal, which prevents postprandial hypercalcemia. | ||
| M10220 | PHM-27 (human) | Peptides |
| PHM-27/PHI, HUMAN | ||
| PHM-27 (human) is a human prepro-vasoactive intestinal polypeptide (27 amino acid). | ||
| M10431 | Recombinant Human Nesfatin-1 (E. coli) | Peptides |
| rHuNesfatin-1 | ||
| Recombinant Human Nesfatin-1 is a metabolic polypeptide and is the N-terminal region of the precursor protein, Nucleobindin2 (encoded by NUCB2 gene). | ||
| M10673 | Procyanidin C1 | Apoptosis |
| PCC1 | ||
| Procyanidin C1 (PCC1) is a natural polyphenol, which causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. | ||
| M11316 | Urolithin C | Calcium Channel |
| Urolithin C, a polyphenol intestinal microbial metabolite of ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is an L-type Ca2+ channel opening agent that enhances Ca2+ influx. Urolithin C induces apoptosis and stimulates the formation of reactive oxygen species (ROS) through mitochondria mediated pathway. | ||
| M11394 | Felypressin | Vasopressin Receptor |
| PLV-2 | ||
| Felypressin (PLV-2) is a non-catecholamine vasoconstrictor and a vasopressin 1 (Vasopressin 1) agonist. Felypressin is widely used in dental surgery. | ||
| M13348 | LyP-1 TFA | Others |
| Lyp-1 TFA is a circular 9-amino acid tumor-targeting peptide that selectively binds its P32 receptor protein in a variety of tumor-associated cells. | ||
| M13447 | Recombinant Human IGF-II (E. coli) | Cytokines and Growth Factors |
| Insulin-like Growth Factor-II; Somatamedin A | ||
| Insulin-like Growth Factor II (IGF-II) is a 7 kDa single chain polypeptide with high homology to insulin. Protein structure：Expressed with an N-terminal Met. Igf-ii (ALA25-GLU91) , Accession # P01344-1. | ||
| M40683 | Recombinant Human RBP4 (HEK293, C-His) | Cytokines and Growth Factors |
| Retinol-Binding Protein 4 | ||
| Human-retinol binding protein is a single-chain polypeptide with a molecular weight of approximately 21000 and one binding site for retinol and other forms of vitamin A. In plasma, RBP4-retinol forms a complex with transthyretin (TTR), also known as thyroxine-binding protein and prealbumin. Defects in RBP4 cause retinol-binding protein deficiency, which affects night vision. | ||
| M14976 | Mulberrin | Others |
| Kuwanon C | ||
| Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC50 value being 1.8 ±1.5 μM. | ||
| M16777 | Salvigenin | Apoptosis |
| Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H2O2-induced cell apoptosis. | ||
| M21404 | Humanin (human) | Others |
| 1-24-Protein humanin (human) | ||
| Humanin (human) (1-24-Protein humanin (human)) is a mitochondrial-derived cytoprotective polypeptide encoded by mitochondrial DNA that is protective against cellular stress and apoptosis in a variety of cell types through a variety of signaling mechanisms including regulation of the JAK/STAT pathway and the interaction of BCL-2 family proteins. | ||
| M24767 | Lupartumab | Others |
| BAY 1112623 | ||
| Lupartumab (BAY 1112623) is an anti-LYPD3 (C4.4A) monoclonal antibody that can be used for the synthesis of antibody-drug conjugate BAY 1129980. | ||
| M25494 | GPLGIAGQ TFA | MMP |
| GPLGIAGQ TFA is a MMP2-cleavable polypeptide, used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. | ||
| M28118 | Cyclotheonamide A | Serine/Threonine Protease |
| Cyclotheonamide A is a serine protease inhibitor (cyclic polypeptide), which can be obtained from marine sponges of the genus Theonella. Cyclotheonamide A shows potent inhibitory activity against trypsin (Ki=0.023 µM) and streptokinase (Ki=0.035 µM) and moderate inhibitory activity against human α-thrombin (Ki=0.18 µM). Cyclotheonamide A can be used in study of antithrombotic. | ||
| M28177 | Macrocarpal A | Antibiotic |
| 10-epi-Eucarobustol F | ||
| Macrocarpal A (10-epi-Eucarobustol F) is an antibacterial agent, which can be isolated from the leaves of Eucalyptus macrocarpa. Macrocarpal A inhibits the growth of Bacillus subtilis PCI219 (minimum inhibitory concentration below 0.2 µM) and Staphylococcus aureus FDA209P (minimum inhibitory concentration is 0.4 µM). | ||
| M28727 | KZR-504 | Proteasome |
| KZR-504 is a highly selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2), with IC50s of 51 nM, 4.274 μM for LMP2 and LMP7, respectively. KZR-504 is of interest for the treatment of autoimmune disease. | ||
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