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(-)-Epigallocatechin gallate

Cat. No. M4208
(-)-Epigallocatechin gallate Structure
Synonym:

EGCG; Epigallocatechol Gallate

Size Price Availability Quantity
20mg USD 30  USD30 In stock
50mg USD 40  USD40 In stock
100mg USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

(-)-Epigallocatechin Gallate (EGCG) inhibits activation EGFR, HER2 and HER3 in the SW837 human colon cancer cell line. (-)-Epigallocatechin Gallate (10 μM) also inhibits cell growth, suppresses activation of EGFR, HER2, and HER3, and causes decrease in the levels of COX-2 and Bcl-xL proteins, and apoptosis after treatment for 96 h. In vivo, (-)-Epigallocatechin Gallate (5, 10, and 20 mg/kg, p.o.) inhibits the growth of orthotopic colorectal cancer cells in mice.

Chemical Information
Molecular Weight 458.37
Formula C22H18O11
CAS Number 989-51-5
Solubility (25°C) DMSO 20 mg/mL
Water 15 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] De Amicis F, et al. J Cell Physiol. Epigallocatechin gallate inhibits growth and epithelial-to-mesenchymal transition in human thyroid carcinoma cell lines.

[2] Jin H, et al. Onco Targets Ther. Epigallocatechin gallate inhibits the proliferation of colorectal cancer cells by regulating Notch signaling.

[3] Tsang WP, et al. J Nutr Biochem. Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells.

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Keywords: (-)-Epigallocatechin gallate, EGCG; Epigallocatechol Gallate supplier, EGFR/HER2, inhibitors, activators


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