All AbMole products are for research use only, cannot be used for human consumption.
Species: Human
Purity: SDS-PAGE analysis, > 95%, HIGH performance liquid chromatography analysis, > 95%
Endotoxin level: protein < 0.2 EU/μg by gel coagulation
Apparent molecular weight: ~7.6 kDa, sdS-PAGE under reduction conditions
Storage and stability: After receiving, the product remains stable at temperatures below -70°C for up to 6 months. After recombination, the product should be stable at 4°C for 1 week or -20°C for 3 months. For long-term preservation, carrier protein (e.g. 0.1% BSA) is recommended. Avoid repeated freeze-thaw cycles
Bioactivity: Insulin-like Growth Factor II (IGF-II) is a 7 kDa single-chain polypeptide with a high degree of homology to insulin. During in-body circulation, IGF-II is complex with IGF binding proteins (IGFBP), which act as a circulating reservoir to transport IGF-II and extend its half-life. The receptor of IGF-II (IGFRs) is a transmembrane tyrosine receptor, which is a heterotetramer composed of two α- and two β- subunits. IGFRs function through intracellular signaling molecules such as IRS, SHC, and PI3K. Igf-ii can promote breast cancer cell proliferation, inhibit death and stimulate transformation.
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH₂O up to 100 μg/ml. |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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