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Human-retinol binding protein is a single-chain polypeptide with a molecular weight of approximately 21000 and one binding site for retinol and other forms of vitamin A. In plasma, RBP4-retinol forms a complex with transthyretin (TTR), also known as thyroxine-binding protein and prealbumin. Defects in RBP4 cause retinol-binding protein deficiency, which affects night vision.
Measured by its ability to bind all-trans retinoic acid, the binding of retinoic acid results in the quenching of Trp fluorescence in RBP4 > 1.0 µM all-trans retinoic acid is bound under the described conditions.
Accession: P02753
Apparent Molecular Weight: ~22 kDa, reducing conditions
Endotoxin < 0.2 EU/μg
Lyophilized from a 0.2 μm filtered solution in 50 mM Tris-HCl, 150 mM NaCl, pH 7.5.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml. |
| Storage | Stable for up to 6 months at ≤ -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. |
[2] Primoz Kotnik et al. PLoS One. Interleukin-1β downregulates RBP4 secretion in human adipocytes
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