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Pluronic F-127

Cat. No. M3825
Pluronic F-127 Structure

Poloxamer 407; Polyethylene-polypropylene glycol; PF-127

Size Price Availability Quantity
5g USD 30  USD30 In stock
10g USD 40  USD40 In stock
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Quality Control & Documentation
  • Purity: Cell culture level
  • COA
  • MSDS
Biological Activity

Pluronic F-127 was used for fluorescent labeling of blood vessels, astrocytes, and neurons. Pluronic F-127 is frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, etc. to improve their water solubility. Pluronic F-127 was used to coat a siliconized coverslip to hold an egg extract in a study. Pluronic F-127 was added to phosphate buffered saline (PBS), to lower unspecific cell and protein adhesion to a PDMS-based microfluidic device.

Chemical Information
CAS Number 9003-11-6
Solubility (25°C) DMSO 200 mg/mL
Water >110 mg/mL (May need warm to 40-50°C)
Storage 2-8°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Filipe E Antunes, et al. Colloids Surf B Biointerfaces. Gels of Pluronic F127 and nonionic surfactants from rheological characterization to controlled drug permeation

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Keywords: Pluronic F-127, Poloxamer 407; Polyethylene-polypropylene glycol; PF-127 supplier, Cell Staining, inhibitors, activators

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