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PHM-27 (human)

Cat. No. M10220

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PHM-27 (human) Structure
Synonym:

PHM-27/PHI, HUMAN

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Biological Activity

PHM-27 (human) is a potent the human calcitonin receptor agonist with an EC50 of 11 nM. PHM-27 (human) efficiently enhances glucose-induced insulin secretion from beta cells by an autocrine mechanism.

Chemical Information
Molecular Weight 2985.41
Formula C135H214N34O40S
CAS Number 87403-73-4
Solubility (25°C) Water 1 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jian-Nong Ma, et al. Biochem Pharmacol. Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor

[2] I Kato, et al. J Biol Chem. Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic beta cells. Evidence for improved glucose tolerance and enhanced insulin secretion by VIP and PHM-27 in vivo

[3] N Itoh, et al. Nature. Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27

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Keywords: PHM-27 (human), PHM-27/PHI, HUMAN supplier, Peptides, inhibitors, activators

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