About 30 results found for searched term "H-7" (0.004 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1710 | Flavopiridol | CDK |
| HMR-1275; Alvocidib; L86-8275 | ||
| Flavopiridol (Alvocidib) is a competitive broad-spectrum CDK inhibitor with IC50 of 30,170,100 nM against CDK1, CDK2 and CDK4, respectively. | ||
| M1736 | CH5132799 | PI3K |
| Izorlisib | ||
| CH5132799 is a novel and potent class I PI3K inhibitor with IC50 value of 0.014 μM. | ||
| M1769 | PHA-739358 (Danusertib) | Aurora Kinase |
| Danusertib | ||
| PHA-739358 (Danusertib) is a small molecule with low nanomolar activity against all aurora kinases (AKs) with IC50 value of 13 nM for aurora-A and 79 nM for aurora-B respectively. | ||
| M1807 | SCH727965 (dinaciclib) | CDK |
| Dinaciclib | ||
| SCH727965 (Dinaciclib) is a potent and selective CDK inhibitor with IC50 values of 1, 1, 3 and 4 nM for CDK2, CDK5, CDK1 and CDK9, respectively. | ||
| M1872 | Fasudil hydrochloride | ROCK |
| HA-1077; AT877 | ||
| Fasudil hydrochloride is a potent Rho-associated kinase inhibitor with IC50 of 10.7 μM. | ||
| M1899 | PHA-665752 | c-Met |
| PHA-665752 is a selective small molecule c-MET inhibitor (Ki of 4 nM, IC50 of 9 nM). | ||
| M1900 | PHT-427 | Akt |
| PHT-427 is a novel dual Akt and PDPK1 inhibitor (Ki of 2.7 μM and 5.2 μM respectively). | ||
| M1913 | Neratinib | EGFR/HER2 |
| HKI-272 | ||
| Neratinib (HKI-272) is an orally available, irreversible inhibitor of Her 2 tyrosine kinase. | ||
| M1996 | SCH 900776 | Checkpoint |
| MK-8776 | ||
| SCH 900776 (MK-8776) is a highly potent and functionally selective CHK1 inhibitor with IC50 of 3 nM. | ||
| M2032 | Vicriviroc Malate | CCR |
| SCH 417690 | ||
| Vicriviroc (SCH 417690) is a pyrimidine CCR5 entry inhibitor of HIV-1 with IC50 of 0.91 nM. | ||
| M2054 | Fasiglifam (TAK-875) Hemihydrate | GPR/FFAR |
| Fasiglifam Hemihydrate; TAK875 hydrate | ||
| Fasiglifam (TAK-875) Hemihydrate is a novel, orally available, selective GPR40 agonist. | ||
| M2063 | P505-15 hydrochloride | Syk |
| PRT062607 hydrochloride; PRT-2607 hydrochloride; BIIB-057 hydrochloride | ||
| P505-15 (PRT062607) is a novel, highly selective inhibitor of Syk with IC50 value of 1-2 nM. | ||
| M2074 | NVP-BHG712 | VEGFR/PDGFR |
| NVP-BHG712 is a very potent, selective inhbitor of the receptor tyrosine kinase EphB4 (ED50 = 25 nM). | ||
| M2076 | SP600125 | JNK |
| JNK Inhibitor II; 1PMV; NSC75890; Pyrazolanthrone | ||
| SP600125 is a novel and selective inhibitor of c-Jun N-terminal kinase (JNK), inhibited phosphorylation of c-Jun with an IC50 of 5-10 microM. | ||
| M2084 | SCH772984 | ERK |
| SCH772984 is a novel and selective inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. | ||
| M2136 | PH-797804 | p38 MAPK |
| PH-797804 is a highly selective and potent inhibitor of p38 MAP kinase with IC50 of 26 nM. | ||
| M2161 | Navarixin | CXCR |
| SCH 527123; MK-7123 | ||
| Navarixin (SCH 527123) is a novel, selective CXCR2 receptor antagonist with IC50 of 3 nM. Navarixin (SCH 527123) has Kd values of 41 nM for cynomolgus CXCR1 and 0.20 nM, 0.20 nM, 0.08 nM for mouse, rat and cynomolgus monkey CXCR2, respectivelly. | ||
| M2197 | Sulfasalazine | Ferroptosis |
| Salazopyrin; Azulfidine; Sulphasalazine; SAS; NSC 667219 | ||
| Sulfasalazine is a sulfonamide agent derived from Mesalazine. Sulfasalazine has xC-system inhibitory activity associated with iron death and is primarily used as an anti-inflammatory agent. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer. | ||
| M2217 | Mitoxantrone dihydrochloride | Topoisomerase |
| Mitozantrone dihydrochloride; NSC 301739 dihydrochloride | ||
| Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. | ||
| M2228 | Methotrexate | Antifolate |
| Amethopterin; CL14377; WR19039 | ||
| Methotrexate (Amethopterin) is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. | ||
| M2278 | Bosentan Hydrate | Endothelin Receptor |
| Benzenesulfonamide Hydrate; Ro-47-0203 Hydrate | ||
| Bosentan is an endothelin (ET) receptors antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. | ||
| M2284 | Tosedostat | Aminopeptidase |
| CHR2797 | ||
| CHR-2797 is an aminopeptidase inhibitor for LAP, PuSA and Aminopeptidase N with IC50 of 100 nM, 150 nM and 220 nM, respectively. | ||
| M2312 | AG-1478 | EGFR/HER2 |
| Tyrphostin AG-1478; NSC 693255 | ||
| AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor with IC50 of 3 nM. | ||
| M11172 | Reslizumab | IL Receptor/Related |
| Sch 55700 | ||
| Reslizumab (Sch 55700) is a humanized monoclonal antibody targeting human interleukin 5 (IL-5) for the study of eosinophilic asthma. Reslizumab effectively blocks il-5 function. Reslizumab inhibited IL-5-dependent cell proliferation with an IC50 of about 91.1 pM. | ||
| M2322 | PHA-767491 | CDK |
| CAY10572 | ||
| PHA-767491 is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively. | ||
| M2327 | Daunorubicin hydrochloride | DNA/RNA Synthesis |
| Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride | ||
| Daunorubicin (Daunomycin) HCl is a topoisomerase II inhibitor, inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. | ||
| M2339 | SCH 1473759 | Aurora Kinase |
| SCH1473759 | ||
| SCH 1473759 is a novel subnanometer Aurora A /B inhibitor with IC50 of 4 nM and 13 nM, respectively. | ||
| M2411 | Picropodophyllin (AXL1717) | IGF-1R |
| Picropodophyllotoxin; CAS# 17434-18-3; PPP | ||
| AXL1717 (picropodophyllin, Picropodophyllotoxin, PPP) is a non-competitive, potent, and specific inhibitor of IGF-1Rα/β with IC50 of 1 nM. | ||
| M2473 | Broxyquinoline | Parasite |
| Dibromohydroxyquinoline; 5,7-Dibromo-8-hydroxyquinoline | ||
| Broxyquinoline is an antiprotozoal agent and able to release oxygen free radicals from the water in mucous membranes. | ||
| M2504 | CFTR(inh)-172 | CFTR |
| CFTR inhibitor 172 | ||
| CFTR(inh)-172 is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters. | ||
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