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Broxyquinoline

Cat. No. M2473
Broxyquinoline Structure
Synonym:

Dibromohydroxyquinoline; 5,7-Dibromo-8-hydroxyquinoline

Size Price Availability Quantity
100mg USD 55  USD55 In stock
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Quality Control & Documentation
Biological Activity

Broxyquinoline is an antiprotozoal agent and able to release oxygen free radicals from the water in mucous membranes.

Chemical Information
Molecular Weight 302.95
Formula C9H5Br2NO
CAS Number 521-74-4
Form Solid
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] L A Rodriguez, et al. The metabolism of the 5-7-dibromo-8-hydroxyquinoline (broxyquinoline) in man

[2] S S Manchanda, et al. Broxyquinoline and brobenzoxalidine suspension (Intestopan-AI 307) in childhood diarrhoea. A clinical trial on 533 children

[3] B Strandvik, et al. Amaurosis after broxyquinoline

[4] R Swain, et al. A study on the neurotoxicity of broxyquinoline and brobenzoxaldine combination in therapeutic doses

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Keywords: Broxyquinoline, Dibromohydroxyquinoline; 5,7-Dibromo-8-hydroxyquinoline supplier, Parasite, inhibitors, activators


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