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Nanaomycin A is the first selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM. Nanaomycin A (0.5, 5 μM; 72 hours) reveals induction of RASSF1A protein expression in A549 cells.
| Molecular Weight | 302.28 |
| Formula | C16H14O6 |
| CAS Number | 52934-83-5 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 15 mg/mL |
| Storage | Powder -20°C |
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