About 23 results found for searched term "FAS-IN-1" (0.121 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M14433 | FASN-IN-1 | FAS |
| FASN-IN-1 is a fatty acid synthase (FASN) inhibitor. | ||
| M22360 | FAS-IN-1 | Others |
| FAS-IN-1 | ||
| M1872 | Fasudil hydrochloride | ROCK |
| HA-1077; AT877 | ||
| Fasudil hydrochloride is a potent Rho-associated kinase inhibitor with IC50 of 10.7 μM. | ||
| M2197 | Sulfasalazine | Ferroptosis |
| Salazopyrin；Azulfidine；Sulphasalazine; SAS | ||
| Sulfasalazine is a sulfonamide agent derived from Mesalazine. Sulfasalazine has xC-system inhibitory activity associated with iron death and is primarily used as an anti-inflammatory agent. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer. | ||
| M3607 | Fasudil | ROCK |
| AT-877; HA-1077 | ||
| Fasudil (HA-1077) is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively. | ||
| M5260 | Hydroxyfasudil hydrochloride | ROCK |
| HA-1100 HCl | ||
| Hydroxyfasudil (HA-1100), an active metabolite of fasudil hydrochloride, is a specific Rho-kinase(ROCK) inhibitor with IC50 values of 0.73 μM and 0.72 μM for ROCK1 and ROCK2, respectively. | ||
| M7805 | Fasentin | Others |
| Fasentin is a novel inhibitor of glucose uptake, GluT1 inhibitor. | ||
| M8622 | TVB-3166 | FAS |
| TVB3166 | ||
| TVB-3166 is a cell-permeable pyrrazole derivative that inhibits cellular palmitate synthesis (IC50 <100 nM) by fatty acid synthase (FASN) keto-reductase activity in a potent and reversible manner (IC50 = 42 nM), effectively inhibiting palmitate-dependent survival of various cancer cells in cultures and xenografted tumor growth in mice vivo (60-100 mg/kg/d p. | ||
| M13728 | Hydroxyfasudil | ROCK |
| HA-1100 | ||
| Hydroxyfasudil is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively. | ||
| M14432 | FASN-IN-4 tosylate | FAS |
| FASN-IN-4 tosylate is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29). FASN-IN-4 tosylate also inhibits SARS-CoV-2 with an EC50 of 18.6 nM. | ||
| M24572 | Fasinumab | Others |
| Fasinumab (Anti-Human NGF) is a human IgG1k monoclonal antibody to nerve growth factor (NGF). Fasinumab can be used in acute sciatica and knee osteoarthritis (OA) studies. | ||
| M24646 | Lifastuzumab vedotin | Drug-Linker Conjugates for ADC |
| DNIB0600A | ||
| Lifastuzumab vedotin (DNIB0600A) is an antibody-drug conjugate (ADC) that comprises a humanized IgG1 anti-NaPi2b monoclonal antibody (MNIB2126A) and a potent antimitotic agent, monomethyl auristatin E (MMAE), which inhibits cell division by blocking the polymerization of tubulin. | ||
| M24666 | Tafasitamab | Apoptosis |
| XmAb5574; MOR00208; zz-cxix | ||
| Tafasitamab (XmAb5574) is an Fc-modified, humanized monoclonal antibody that binds to the human B-cell surface antigenCD19. | ||
| M24724 | Afasevikumab | IL Receptor/Related |
| RG 7624; RO 5553110; NI-1401 | ||
| Afasevikumab (RG 7624; RO 5553110; NI-1401) is a fully human monoclonal IgG1κ antibody neutralizing both IL-17A and IL-17F. Afasevikumab has anti-inflammatory activities. | ||
| M28252 | GSK837149A | FAS |
| GSK837149A is a selective inhibitor of human Fatty Acid Synthase (FASN) targeting the KR domain. GSK837149A has reversible inhibition effect on FASN and selectivity for type I FASN (Ki=30 nM). GSK837149A is also a competitive inhibitor of NADPH and a non-competitive inhibitor of acetoacetyl-CoA. GSK837149A can be used for the research of obesity and breast cancer. | ||
| M28418 | BMS-962212 | Factor Xa |
| BMS-962212 is a direct, reversible, selective factor XIa (FXIa) inhibitor . BMS-962212 is well tolerated, with fast onset of pharmacodynamic (PD) responses and rapid elimination. BMS-962212 increases exposure dependently in activated partial thromboplastin time, and decreases exposure dependently in FXI clotting activity. | ||
| M28586 | LML134 | Histamine Receptor |
| LML134 (compound 18b) is an orally active and high selective Histamine 3 receptor (H3R) inverse agonist with Kis of 0.3 nM and 12 nM for hH3R cAMP and hH3R bdg. LML134 penetrates the brain rapidly, leading to high H3R occupancy, and disengages its target with a fast kinetic profile. LML134 has the potential for excessive sleep disorders. | ||
| M28999 | Onfasprodil | GluR |
| Onfasprodil is negative allosteric modulator of NR2B. Onfasprodil in combination with GABA receptor regulator has the potential for the research of Alzheimer's disease (extracted from patent CN111481543A). | ||
| M29270 | PXS-5153A | Monoamine Oxidase |
| PXS-5153A is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC50 of <40 nM for LOXL2 across all mammalian species and an IC50 of 63 nM for human LOXL3. PXS-5153A could reduce crosslinks and ameliorates fibrosis. | ||
| M29378 | MS177 | PROTAC |
| MS177 is an effective and fast-acting EZH2 degrader. MS177 is a PROTAC that consists of a CRBN ligand, linker, and a potent enzymatic EZH2 inhibitor C24 (C24 IC50): 12 nM). MS177 effectively depletes both canonical EZH2–PRC2 and noncanonical EZH2–cMyc complexes. MS177 induces leukaemia cell growth inhibition, apoptosis and cell cycle progression arrest. | ||
| M29492 | VZ185 | PROTAC |
| VZ185 is a potent, fast, and selective von Hippel-Lindau based dual degrader probe of BRD9 and BRD7 with DC50s of 4.5 and 1.8 nM, respectively. VZ185 is cytotoxic in EOL-1 and A-402 cells, with EC50s of 3 nM and 40 nM, respectively. | ||
| M31063 | PXS-5153A monohydrochloride | Monoamine Oxidase |
| PXS-5153A monohydrochloride is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC50 of <40 nM for LOXL2 across all mammalian species and an IC50 of 63 nM for human LOXL3. PXS-5153A monohydrochloride could reduce crosslinks and ameliorates fibrosis. | ||
| M45375 | WSP-1 | Fluorescent Dye |
| WSP-1 is a selective, fast-reacting H2S-specific fluorescent dye that reacts with H2S and releases fluorophores (Ex/Em=465/515 nm). | ||
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