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VZ185 

Cat. No. M29492

All AbMole products are for research use only, cannot be used for human consumption.

VZ185  Structure

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Quality Control & Documentation
Biological Activity

VZ185 is a potent, fast, and selective von Hippel-Lindau based dual degrader probe of BRD9 and BRD7 with DC50s of 4.5 and 1.8 nM, respectively. VZ185 is cytotoxic in EOL-1 and A-402 cells, with EC50s of 3 nM and 40 nM, respectively.

Chemical Information
Molecular Weight 995.21
Formula C53H67FN8O8S
CAS Number 2306193-61-1
Form Solid
Solubility (25°C) DMSO 200 mg/mL (ultrasonic)
Storage Powder -20°C
References

[1] Vittoria Zoppi, et al. J Med Chem. Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7

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  Catalog
Abmole Inhibitor Catalog




Keywords: VZ185  supplier, PROTAC, inhibitors, activators

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