About 30 results found for searched term "AR-A 2" (0.018 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1641 | Quizartinib (AC220) | FLT3 |
| AC220 | ||
| Quizartinib (AC220) is a uniquely potent and selective FLT3 inhibitor. | ||
| M1879 | XL147 | PI3K |
| Pilaralisib; SAR245408 | ||
| XL147 (SAR245408) is an orally bioavailable, selective small molecule Class I PI3K kinase family inhibitor. | ||
| M2028 | Fludarabine | STAT |
| Fludara; NSC 118218; Fludarabinum; F-ara-A | ||
| Fludarabine (NSC 118218) is a STAT1 activation inhibitor and a DNA synthesis inhibitor. Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. Fludarabine markedly inhibited VSMC proliferation in cell culture. Fludarabine also induces significant reduction of STAT-1 phosphorylation, whereas it does not change JAK2 activation. Fludarabine exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. | ||
| M2468 | Brimonidine Tartrate | Adrenergic Receptor |
| Brimonidine tartrate; AGN190342 tartrate; UK14304 tartrate | ||
| Brimonidine Tartrate is a highly selective α-adrenergic receptor antagonist with an EC50 of 0.45 nM for α2A adrenoreceptor, and has been used to study open-angle glaucoma or ocular hypertension. | ||
| M3447 | PF-2545920 | PDE |
| Mardepodect; CAS# 898562-94-2 | ||
| PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with >1000-fold selectivity over the PDE. | ||
| M3699 | Letrozole | Animal Modeling |
| Femara; CGS 20267 | ||
| Letrozole is an orally active, potent, selective, nonsteroidal, third-generation aromatase (CYP19A1) inhibitor, a synthetic benzyltriazole derivative, which is used in the construction of animal models of polycystic ovary syndrome (PCOS), as well as in studies related to postoperative hormone-responsive breast cancer. | ||
| M1621 | Ustekinumab | IL Receptor/Related |
| Anti-IL-12/IL-23,Stelara, CNTO 1275 | ||
| Ustekinumab is a human monoclonal antibody that targets IL12 and IL23, natural proteins that regulate the immune system and immune-mediated inflammatory diseases. | ||
| M1293 | Artesunate | STAT |
| WR-256283; ART; Armax 200; SM-804; HSDB-7458; AS | ||
| Artesunate is a potential STAT3 inhibitor that acts on the small cell lung cancer cell line H69 with an IC50 value of < 5 μM and is also used in antimalarial studies. Artesunate also promotes ROS signaling and lipid peroxidation by increasing the formation of variable iron pools, ultimately leading to iron death in pancreatic cancer cells. | ||
| M4240 | Shikonin | TNF Receptor |
| C.I. 75535; Isoarnebin 4; CAS# 54952-43-1 | ||
| Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844) is an effective and specific inhibitor of Pyruvate kinase M2 (PKM2). Shikonin is the main ingredient of Lithosia, a Chinese herb with a variety of biological activities. Shikonin acts as an anti-inflammatory by inhibiting tumor necrosis factor-α (TNF-α), Proteasome can inhibit the activation of nuclear factor-κB (NF-κB) signaling pathway. | ||
| M4991 | Dihydroartemisinin | Parasite |
| β-Dihydroartemisinin; DHA; Artenimol; CAS# 81496-82-4 | ||
| Dihydroartemisinin is a potent anti-malaria agent. Dihydroartemisinin, a derivative of artemisinin in which the C-10 lactone group is replaced by hemiacetals and active metabolites of all artemisinin compounds, is a widely used antimalarial compound that effectively induces iron death in acute myeloid leukemia cells (HL60, KG1, and THP-1) by regulating iron metabolism. | ||
| M5140 | 2-Deoxy-D-glucose | Cell Culture |
| 2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose | ||
| 2-Deoxy-D-Glucose (2-DG) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which cannot be further metabolized by phosphoglucose isomerase. | ||
| M5479 | Carsalam | Others |
| Carbonylsalicylamide; 2H-1,3-Benzoxazine-2,4(3H)-dione | ||
| Carsalam (Carbonylsalicylamide) is a non-steroidal anti-inflammatory compound. | ||
| M5619 | Eptifibatide | Integrin |
| MPA-HAR-Gly-Asp-Trp-Pro-Cys-NH2; {MPA}{HAR}GDWPC-NH2 | ||
| Eptifibatide is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class. | ||
| M6170 | Bedaquiline fumarate | Antibiotic |
| R403323; TMC207 fumarate; R207910 fumarate | ||
| Bedaquiline fumarate, a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections. | ||
| M6289 | Erythromycin cyclocarbonate | Antibiotic |
| Erythromycin cyclic carbonate; Erythromycin A 11,12-carbonate | ||
| Erythromycin Cyclocarbonate, derivative of Erythromycin, inhibits protein synthesis of bacteria by binding to the 50S ribosome. | ||
| M6562 | Cardiogenol C hydrochloride | Others |
| Cardiogenol C HCl; CAS#: 671225-39-1 (free base) | ||
| Cardiogenol C hydrochloride is a diaminopyrimidine compound that induces the differentiation of MHC- (myosin heavy chain) positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 µM. | ||
| M8683 | Vosaroxin hydrochloride | Topoisomerase |
| SNS-595 Hydrochloride; Vosaroxin Hydrochloride; AG 7352 Hydrochloride; Voreloxin Hydrochloride | ||
| Vosaroxin hydrochloride is a novel quinolone derivative and first-in-class topoisomerase II inhibitor for AML-related studies. | ||
| M9212 | Aramchol | Stearoyl-CoA Desaturase |
| Arachidyl amido cholanoic acid; C20-FABAC; Icomidocholic acid | ||
| Aramchol is a novel fatty acid bile acid coupling agent with oral activity and an inhibitor of SCD1, which acts by inhibiting SCD1 expression in hepatocytes and hepatic astrocytes, and can be used in studies related to non-alcoholic steatohepatitis (NASH). | ||
| M9569 | Etrumadenant | Adenosine Receptor |
| AB928; A2aR/A2bR antagonist-1 | ||
| Etrumadenant (AB928, A2aR/A2bR antagonist-1) is an orally bioavailable, dual antagonist of the A2aR and A2bR adenosine receptors, leads to greater immunomodulatory activity and reduced tumor growth. | ||
| M9712 | Pyrocatechuic acid | Metabolite/Endogenous Metabolite |
| 2,3-Dihydroxybenzoic acid; Catecholcarboxylic acid; NSC 27435 | ||
| Pyrocatechuic acid (2,3-Dihydroxybenzoic acid) is a normal human benzoic acid metabolite found in plasma, and has increased levels after aspirin ingestion. | ||
| M10558 | Recombinant human VEGF-C (HEK 293) | Cytokines and Growth Factors |
| Vascular endothelial growth factor C; VEGF-C (Ala112-Arg227) | ||
| Recombinant human VEGF-C (rhVEGF-C) is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis, lymphangiogenesis and endothelial cell growth and survival, and can also affect the permeability of blood vessels. | ||
| M10570 | Adrenorphin (Metorphamide) | Opioid Receptor |
| Metorphamide; Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2 | ||
| Adrenorphin (Metorphamide) is a opioid octapeptide, acting as a potent agonist of μ-opioid receptor, with Ki of 12 nM. | ||
| M10635 | Fumaric acid | Metabolite/Endogenous Metabolite |
| Fumarate; 2-Butenedioic acid; Trans-Butenedioic acid | ||
| Fumaric acid (Fumarate, 2-Butenedioic acid, Trans-Butenedioic acid) is an intermediate in the citric acid cycle used by cells to produce energy in the form of adenosine triphosphate (ATP) from food. | ||
| M11034 | Netarsudil (AR-13324) 2HCl | ROCK |
| AR-13324 | ||
| Netarsudil (AR-13324) is a Rho-kinase (ROCK) inhibitor with Ki values of 0.2-10.3 nM with potential intraocular pressure (IOP) lowering activity that inhibits both the ROCK and Rho pathways and increases atrial humor (AH) outflow and lowers IOP via the trabecular pathway, and may be used in glaucoma-related studies. | ||
| M11378 | Cardiotoxin Analog (CTX) IV (6-12) | Others |
| Cardiotoxin Analog (CTX) IV (6-12) is a Cardiotoxin analogue IV. Cardiotoxin Analogues IV, isolated from the venom of the Taiwan cobra, is a unique snake venom Cardiotoxin. | ||
| M11498 | 2-Ketoglutaric acid | Tyrosinase |
| alpha-ketoglutarate； alpha-ketoglutaric acid；2-oxoglutaric acid | ||
| 2-ketoglutaric acid (alpha-ketoglutaric acid) is an intermediate produced by ATP or GTP in the Krebs cycle. 2-ketoglutaric acid also acts as the main carbon skeleton for nitrogen assimilation. 2-ketoglutaric acid is a reversible inhibitor of Tyrosinase (IC50=15 mM). | ||
| M14049 | PAR-4 Agonist Peptide, amide TFA | PAR |
| PAR-4-AP TFA; AY-NH2 TFA | ||
| PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA; AY-NH2 TFA) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist. | ||
| M15014 | Recombinant Human Carboxypeptidase M (HEK293,C-6His) | Cytokines and Growth Factors |
| Carboxypeptidase M;CPM | ||
| Carboxypeptidase M (CPM) plays important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins. It is widely distributed in a variety of tissues and cells. | ||
| M14716 | Ibiglustat (L-Malic acid) | Glucosylceramide Synthase |
| Venglustat (L-Malic acid); SAR402671 (L-Malic acid); GZ402671 (L-Malic acid) | ||
| Ibiglustat (Venglustat) L-Malic acid is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. | ||
| M14807 | Cibinetide | Peptides |
| ARA290 | ||
| Cibinetide (ARA290) is an EPO-derivative, acting as a specific agonist of erythropoietin/CD131 heteroreceptor, and used for the research of neurological disease. | ||
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