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Adrenorphin (Metorphamide)

Cat. No. M10570
Adrenorphin (Metorphamide) Structure
Synonym:

Metorphamide; Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2

Size Price Availability
1mg USD 72  USD72 4-7 Days
5mg USD 218  USD218 4-7 Days
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Quality Control
  • Current batch:
  • Purity >96%
  • COA
  • MSDS
Biological Activity

Adrenorphin (Metorphamide) is a opioid octapeptide, acting as a potent agonist of μ-opioid receptor, with Ki of 12 nM. The binding ratios of Ki for μ-opioid receptor/Ki for δ-opioid receptor is 0.04, and the binding ratios of Ki for μ-opioid receptor/Ki for κ-opioid receptor is 0.46. Adrenorphin potently inhibits catecholamine secretion evoked by 10 μM nicotine in cultured human pheochromocytoma 6 cells, with IC50 of 1.1 μM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 984.18
Formula C44H69N15O9S
CAS Number 88377-68-8
Purity >96%
Solubility DMSO 48 mg/mL
Storage at -20°C
References

[1] E Weber, et al. Proc Natl Acad Sci U S A. Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain

[2] T Yanase, et al. J Clin Endocrinol Metab. Studies on adrenorphin in pheochromocytoma

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Keywords: Adrenorphin (Metorphamide), Metorphamide; Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2 supplier, Opioid Receptor, inhibitors

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