2-ketoglutaric acid (alpha-ketoglutaric acid) is an intermediate produced by ATP or GTP in the Krebs cycle. 2-ketoglutaric acid also acts as the main carbon skeleton for nitrogen assimilation. 2-ketoglutaric acid is a reversible inhibitor of Tyrosinase (IC50=15 mM).
| Molecular Weight | 146.1 |
| Formula | C5H6O5 |
| CAS Number | 328-50-7 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 20 mg/mL |
| Storage | 2-8°C |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Dunxin Shen, et al. Anal Biochem. Synthesis of α-Ketoglutaramic acid
[3] Zbigniew Zasłona, et al. Mol Cell. Cytokine-like Roles for Metabolites in Immunity
[4] Elisa Elena Baracco, et al. Aging (Albany NY). α-Ketoglutarate inhibits autophagy
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