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Recombinant human VEGF-C (HEK 293)

Cat. No. M10558
Recombinant human VEGF-C (HEK 293) Structure
Synonym:

Vascular endothelial growth factor C; VEGF-C (Ala112-Arg227)

Size Price Availability Quantity
10ug USD 180  USD180 In stock
50ug USD 380  USD380 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

VEGF-C (rhVEGF-C) is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis, lymphangiogenesis and endothelial cell growth and survival, and can also affect the permeability of blood vessels. VEGF-C forms cell surface-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors.

Measured in a cell proliferation assay using HMVEC human microvascular endothelial cells, the ED50 for this effect is < 0.5 µg/mL.

Recombinant human VEGF-C expressed the target gene encoding Ala112-Arg227 with an N-terminal Met.


Accession: P49767

Endotoxin < 0.2 EU/μg

Apparent Molecular Weight: 16~19 kDa, reducing conditions

Lyophilized after extensive dialysis against PBS.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for up to 6 months after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Barbara Le Bras, et al. Nat Neurosci. VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain

[2] V Joukov, et al. EMBO J. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases

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Keywords: Recombinant human VEGF-C (HEK 293), Vascular endothelial growth factor C; VEGF-C (Ala112-Arg227) supplier, Recombinant Proteins, inhibitors, activators


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