Purity: > 95% as determined by reduced SDS-PAGE
Endotoxin: less than 0.1 ng/ug (1 EU/ug) as tested by LAL
Storage and stability: storage temperature ≤-70℃, after receiving the goods can be stably stored for 6 months. After opening, store in aseptic condition for 3 months, storage temperature ≤-70℃. Please minimize freeze-thaw cycles.
Biological activity: Carboxypeptidase M (CPM) specifically removes c-terminal bases (arginine or lysine) from polypeptides and proteins. Carboxypeptidase plays a role in physiological processes such as coagulation/fibrinolysis, inflammation, food digestion, hormone promotion and neuropeptide processing. CPM is thought to play an important role in controlling the activity of peptide hormones and growth factors on the cell surface, as well as in membrane localization and degradation of extracellular proteins. It is widely distributed in various tissues and cells. CPM is involved in peptide metabolism on cell surface and extracellular fluid. CPM is not only a protease, but also a binding partner for cell surface protein-protein interactions.
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Recombinant Proteins Products |
|---|
| Recombinant Human Serpin A12 (E.coli, N-GST)
Vaspin (Visceral Adipose-Specific SERPIN) is a newly described adipokine. Vaspin is also a unique insulin sensitizing adipocytokine in obesity. |
| Recombinant Human B2M Protein (Mammalian, C-6His)
β-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family. B2M may adopt the fibrillar configuration of amyloid in certain pathologic states. |
| Recombinant Mouse E-Selectin/CD62E Protein (HEK293)
E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes involved in cancer cell metastasis. |
| Recombinant Human DPP4/CD26 (Mammalian, C-6His)
DPP4/CD26 is a signal-anchor for type II membrane protein that belongs to the peptidase S9B family. DPP4/CD26 acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. It’s binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. |
| Recombinant Human USP14 (E.coli, N-6His)
USP14 belongs to the ubiquitin-specific processing (USP) family which is a deubiquitinating enzyme (DUB) with His and Cys domains. USP14 acts also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
