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Aramchol is an orally active novel fatty acid bile acid coupling agent and an inhibitor of SCD1, which acts by inhibiting SCD1 expression in hepatocytes and hepatic astrocytes: in hepatocytes, inhibition of SCD1 reduces monounsaturated fatty acid synthesis, promotes cholesterol reverse transporter, reduces hepatic lipid accumulation, increases GSH/GSSG ratio, and reduces hepatic oxidative stress; in hepatic astrocytes, inhibition of SCD1 results in specific up-regulation of PPARγ, which prevents collagen production. Hepatic oxidative stress; in hepatic astrocytes, inhibition of SCD1 leads to specific up-regulation of PPARγ, thus preventing collagen production. Can be used in studies related to non-alcoholic steatohepatitis (NASH).
| Molecular Weight | 702.10 |
| Formula | C44H79NO5 |
| CAS Number | 246529-22-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Stearoyl-CoA Desaturase Products |
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Flurtamone is a chiral herbicide with acute toxicity levels to Selenastrum capricornutum. |
| SSI-4
SSI-4 is an inhibitor of Stearoyl CoA desaturase 1 (SCD1) , which can be modified with 11C, used as a ligand to in vivo small animal PET/CT imaging of SCD1. |
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