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Ibiglustat (L-Malic acid)

Cat. No. M14716
Ibiglustat (L-Malic acid) Structure
Synonym:

Venglustat (L-Malic acid); SAR402671 (L-Malic acid); GZ402671 (L-Malic acid)

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Quality Control & Documentation
Biological Activity

Ibiglustat (Venglustat) L-Malic acid is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat L-Malic acid can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.

Chemical Information
Molecular Weight 523.57
CAS Number 1629063-78-0
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zhen Wei, et al. Microbial Biosynthesis of L-Malic Acid and Related Metabolic Engineering Strategies: Advances and Prospects

[2] Aline Kvilein, et al. Acetate as substrate for L-malic acid production with Aspergillus oryzae DSM 1863

[3] Weifeng Cao, et al. Membrane-assisted β-poly(L-malic acid) production from bagasse hydrolysates by Aureobasidium pullulans ipe-1

[4] Zhe Chi, et al. Poly(β-L-malic acid) (PMLA) from Aureobasidium spp. and its current proceedings

[5] Zhe Chi, et al. Microbial biosynthesis and secretion of l-malic acid and its applications

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Keywords: Ibiglustat (L-Malic acid), Venglustat (L-Malic acid); SAR402671 (L-Malic acid); GZ402671 (L-Malic acid) supplier, inhibitors, activators

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