Ibiglustat (Venglustat) L-Malic acid is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat L-Malic acid can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.
|Solubility (25°C)||DMSO ≥ 90 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Zhen Wei, et al. Microbial Biosynthesis of L-Malic Acid and Related Metabolic Engineering Strategies: Advances and Prospects
 Aline Kvilein, et al. Acetate as substrate for L-malic acid production with Aspergillus oryzae DSM 1863
 Weifeng Cao, et al. Membrane-assisted β-poly(L-malic acid) production from bagasse hydrolysates by Aureobasidium pullulans ipe-1
 Zhe Chi, et al. Poly(β-L-malic acid) (PMLA) from Aureobasidium spp. and its current proceedings
 Zhe Chi, et al. Microbial biosynthesis and secretion of l-malic acid and its applications
|Dextran (Mw 150000)
Dextran is a multipurpose branched glucan, which can improve plasma colloid osmotic pressure, increase blood volume, reduce platelet adhesion, inhibit red blood cell aggregation, reduce blood viscosity, reduce peripheral circulation resistance, and unclog microcirculation.
Zeatin is a coconut milk-derived plant hormone and is a common plant cytokinin that is found in the developing or meristematic tissues and organs such as roots, shoot apex, immature organs, and others.
Carbidopa monohydrate is a dopa decarboxylase (DDC) inhibitor, which can be used for the research of Parkinson's disease. Carbidopa monohydrate is also a selective aryl hydrocarbon receptor (AhR) modulator.
|Poly-L-lysine (MW 15000~30000)
Poly-L-lysine (MW 15000~30000)
|Poly-L-lysine (MW 30000~70000)
Poly-L-lysine (MW 30000~70000)
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