Free shipping on all orders over $ 500

Ibiglustat (L-Malic acid)

Cat. No. M14716
Ibiglustat (L-Malic acid) Structure

Venglustat (L-Malic acid); SAR402671 (L-Malic acid); GZ402671 (L-Malic acid)

Size Price Availability
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Ibiglustat (Venglustat) L-Malic acid is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat L-Malic acid can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.

Chemical Information
Molecular Weight 523.57
CAS Number 1629063-78-0
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Zhen Wei, et al. Microbial Biosynthesis of L-Malic Acid and Related Metabolic Engineering Strategies: Advances and Prospects

[2] Aline Kvilein, et al. Acetate as substrate for L-malic acid production with Aspergillus oryzae DSM 1863

[3] Weifeng Cao, et al. Membrane-assisted β-poly(L-malic acid) production from bagasse hydrolysates by Aureobasidium pullulans ipe-1

[4] Zhe Chi, et al. Poly(β-L-malic acid) (PMLA) from Aureobasidium spp. and its current proceedings

[5] Zhe Chi, et al. Microbial biosynthesis and secretion of l-malic acid and its applications

Related Products
Dextran (Mw 150000)

Dextran is a multipurpose branched glucan, which can improve plasma colloid osmotic pressure, increase blood volume, reduce platelet adhesion, inhibit red blood cell aggregation, reduce blood viscosity, reduce peripheral circulation resistance, and unclog microcirculation.


Zeatin is a coconut milk-derived plant hormone and is a common plant cytokinin that is found in the developing or meristematic tissues and organs such as roots, shoot apex, immature organs, and others.

Carbidopa monohydrate

Carbidopa monohydrate is a dopa decarboxylase (DDC) inhibitor, which can be used for the research of Parkinson's disease. Carbidopa monohydrate is also a selective aryl hydrocarbon receptor (AhR) modulator.

Poly-L-lysine (MW 15000~30000)

Poly-L-lysine (MW 15000~30000)

Poly-L-lysine (MW 30000~70000)

Poly-L-lysine (MW 30000~70000)

Abmole Inhibitor Catalog

Keywords: Ibiglustat (L-Malic acid), Venglustat (L-Malic acid); SAR402671 (L-Malic acid); GZ402671 (L-Malic acid) supplier, inhibitors, activators

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.