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Ibiglustat

Cat. No. M10279
Ibiglustat Structure
Synonym:

Venglustat; SAR402671; GZ402671

Size Price Availability Quantity
5mg USD 210  USD210 In stock
10mg USD 320  USD320 In stock
25mg USD 600  USD600 In stock
50mg USD 960  USD960 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Ibiglustat (Venglustat) can cross the blood-brain barrier. Ibiglustat can prevent additional GL-3 accumulation and could serve to ameliorate the abundant levels of this sphingolipid in FD cardiomyocytes.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 389.49
Formula C20H24FN3O2S
CAS Number 1401090-53-6
Purity >99%
Solubility DMSO ≥ 40 mg/mL
Storage at -20°C
References

[1] Iva Stojkovska, et al. Cell Tissue Res. Molecular mechanisms of α-synuclein and GBA1 in Parkinson's disease

[2] Jean-Michel Itier, et al. J Inherit Metab Dis. Effective clearance of GL-3 in a human iPSC-derived cardiomyocyte model of Fabry disease

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Ibiglustat, Venglustat; SAR402671; GZ402671 supplier, Transferase, inhibitors

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