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Glucosylceramide synthase-IN-1 (T-036) a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 31 nM and 51 nM for human GCS and mouse GCS, respectively. Glucosylceramide synthase-IN-1 can be used for Gaucher's disease research.
| Molecular Weight | 460.42 |
| Formula | C24H20F4N2O3 |
| CAS Number | 2601393-20-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL (ultrasonic) |
| Storage | 4°C, protect from light, dry, sealed |
[4] Maria C Messner, et al. Adv Exp Med Biol. Glucosylceramide in humans
[5] Richard J Bleicher, et al. Biochim Biophys Acta. Glucosylceramide synthase and apoptosis
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