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Miglustat hydrochloride

Cat. No. M10310
Miglustat hydrochloride Structure
Synonym:

OGT 918 HCl; NB-DNJ HCl; Miglustat HCl

Size Price Availability Quantity
5mg USD 98  USD98 In stock
10mg USD 170  USD170 In stock
25mg USD 340  USD340 In stock
50mg USD 560  USD560 In stock
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Quality Control & Documentation
Biological Activity

Miglustat hydrochloride also known as OGT 918 and NB-DNJ, inhibits glucosylceramide synthase, and is used primarily to treat Type I Gaucher disease (GD1).

Chemical Information
Molecular Weight 255.74
Formula C10H22ClNO4
CAS Number 210110-90-0
Form Solid
Solubility (25°C) Water 30 mg/mL
DMSO 55 mg/mL
Storage -20°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Olga Abian, et al. Mol Pharm. Therapeutic strategies for Gaucher disease: miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imiglucerase

[2] Paul L M van Giersbergen, et al. J Clin Pharmacol. Influence of food intake on the pharmacokinetics of miglustat, an inhibitor of glucosylceramide synthase

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Keywords: Miglustat hydrochloride, OGT 918 HCl; NB-DNJ HCl; Miglustat HCl supplier, Glucosylceramide Synthase, inhibitors, activators


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