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GZ667161 (Genz-667161) is potent, orally available and CNS-penetrant inhibitor of Glucosylceramide synthase (GCS). GZ667161 alleviates aberrations in synucleinopathy models.
| Molecular Weight | 382.47 |
| Formula | C23H27FN2O2 |
| CAS Number | 1401090-10-5 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Glucosylceramide Synthase Products |
|---|
| Eliglustat
Eliglustat inhibits glucosylceramide synthase (GCS), thus reducing the load of glucosylceramide influx into the lysosome. |
| Ibiglustat
Ibiglustat (Venglustat) is a potent and selective Glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor. |
| G43
G43 is a potent, selective glucosyltransferase inhibitor, with the Kd of 3.7μM and 46.9 nM for GtfB and GtfC, respectively. |
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