About 30 results found for searched term "4-ONE" (0.015 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3028 | Spironolactone | Mineralocorticoid Receptor |
| SC9420; Abbolactone | ||
| Spironolactone (SC9420) is an oral active aldosterone mineralocorticoid receptor antagonist with an IC50 value of 24 nM. Spironolactone is also an androgen receptor antagonist with an IC50 of 77 nM. Spironolactone promotes podocyte autophagy. | ||
| M3052 | TCID | Deubiquitinase |
| 4,5,6,7-Tetrachloroindan-1,3-dione | ||
| TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1. | ||
| M3409 | Formestane | Others |
| 4-hydroxyandrostenedione | ||
| Formestane is a second generation selective aromatase inhibitor with an IC50 of 80 nM. | ||
| M3774 | Kenpaullone | CDK |
| NSC-664704, 9-Bromopaullone, 9-Bromo-7 | ||
| Kenpaullone is potent inhibitor of CDK1/cyclin B and GSK-3β with IC50 values of 0.4 and 0.23 μM respectively. | ||
| M4008 | Liquiritigenin | Estrogen Receptor |
| 4',7-Dihydroxyflavanone | ||
| Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC50 of 36.5 nM for activation of the ERE tk-Luc. | ||
| M4540 | Scutellarein | Src-bcr-Abl |
| 6-Hydroxyapigenin; 4',5,6,7-Tetrahydroxyflavone | ||
| Scutellarein is a natural flavonoid with anti-inflammatory effects. | ||
| M4584 | Acacetin | Potassium Channel |
| 5,7-Dihydroxy-4'-methoxyflavone | ||
| Acacetin is a flavonoid compound that has been shown to have anti-cancer, anti-mutagenic, anti-inflammatory and anti-peroxidative effects. | ||
| M5002 | 4'-Chloropropiophenone | Others |
| 4-pyridazinecarboxamides and esters as interleukin-1beta converting enzyme inhibitors . | ||
| M5359 | 2,2′-Dihydroxy-4-methoxybenzophenone | Others |
| Benzophenone-8; UV-24 | ||
| Dioxybenzone is an organic compound used in sunscreen to block UVB and short-wave UVA (ultraviolet) rays. | ||
| M5370 | 5,5-Dimethyloxazolidine-2,4-dione | Metabolite/Endogenous Metabolite |
| Dimethadione, Dimethyloxazolidinedione, Dimethadion | ||
| Dimethadione is an anticonvulsant that is the active metabolite of trimethadione. | ||
| M5479 | Carsalam | Others |
| Carbonylsalicylamide; 2H-1,3-Benzoxazine-2,4(3H)-dione | ||
| Carsalam (Carbonylsalicylamide) is a non-steroidal anti-inflammatory compound. | ||
| M5730 | L-Cycloserine | GABA Receptor |
| (S)-4-Amino-3-isoxazolidone; (S)-Cycloserine | ||
| L-cycloserine irreversibly inhibit GABA pyridoxal 5′-phosphate-dependent aminitransferase in E. coli, as well in the brains of various animals in a time-dependent manner, results in increased levels of gamma-aminobutyric acid (GABA), which is an inhibitory neurotransmitter in vivo. | ||
| M5902 | Progesterone | Animal Modeling |
| Pregn-4-ene-3,20-dione | ||
| Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor. It can be used to construct a model of melasma as well as a model of fibrocystic hyperplasia of the breast. | ||
| M5907 | Propyphenazone | COX |
| 4-Isopropylantipyrine; Isopropylphenazone | ||
| Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors. | ||
| M6038 | Trimethadione | Calcium Channel |
| 3,5,5,-Trimethyloxazolidine-2,4-dione | ||
| Trimethadione is an oxazolidinedione anticonvulsant; commonly used to treat epileptic conditions. | ||
| M6340 | 3PO | PFKFB3 |
| 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one | ||
| 3PO is a novel small-molecule inhibitor of the PFKFB3 isozyme, attenuates the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines with IC50 of 1.4-24 μM. | ||
| M6451 | Apigenin | Cytochrome P450 (e.g. CYP17) |
| 4',5,7-Trihydroxyflavone; Apigenine; Apigenol; C.I. Natural Yellow 1 | ||
| Apigenin is a competitive CYP2C9 inhibitor with a Ki of 2 μM. | ||
| M6826 | INCA-6 | NFAT |
| INCA6; Triptycene-1,4-quinone | ||
| INCA-6 is a inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT). | ||
| M7630 | Butein | PDE |
| 2’,3,4,4’-tetrahydroxy Chalcone | ||
| Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4. Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Butein is a SIRT1 activator. | ||
| M8027 | Brexanolone | GABA Receptor |
| Allopregnanolone; 3α,5α-THP; SAGE-547; 5α-Pregnan-3α-ol-20-one | ||
| Brexanolone (Allopregnanolone) is a positive allosteric modulator of GABAA chloride channel. | ||
| M8392 | Tirapazamine | Apoptosis |
| SR259075; SR4233; Win59075; SML 0552; Tirazone; TPZ | ||
| Tirapazamine (TPZ，SR-4233, WIN 59075) is the first hypoxia-activated prodrug. Tirapazamine kills hypoxic cells by inducing chromosome aberrations and DNA double-strand breaks. Tirapazamine induced cell cycle arrest and apoptosis, and down-regulated HIF-1α, CA-IX and VEGF expression. | ||
| M8806 | 6, 2′, 4′-trimethoxyflavone | Others |
| 6, 2′, 4′-trimethoxyflavone is a selective aryl hydrocarbon receptor (AHR) antagonist with no partial agonist activity. | ||
| M9051 | FCCP | Mitochondrial Related |
| Carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone | ||
| FCCP is a mitochondrial uncoupling agent and an oxidative phosphorylation (OXPHOS) inhibitor. FCCP is often used as an apoptosis inducer. | ||
| M9310 | 4-Methylumbelliferone | Others |
| Hymecromone, 4-MU | ||
| 4-methylumbelliferone is an inhibitor of hyaluronic acid (HA) synthesis, and 4Mu treatment leads to a 50% reduction in CD47mRNA levels with an IC50 value of 0.4mm in mouse models of liver cancer. | ||
| M9828 | 2-D08 | E1/E2/E3 Enzyme |
| 2D08; 2',3',4'-trihydroxyflavone | ||
| 2-D08 is a cell permeable, mechanistically unique inhibitor of protein SUMOylation. 2-D08 also inhibits Axl with an IC50 of 0.49 nM. | ||
| M9942 | Pratensein | Others |
| 5,7,3'-Trihydroxy-4'-methoxyisoflavone | ||
| Pratensein | ||
| M9944 | 7,4'-Dihydroxyflavone | CCR |
| 7,4'-Dihydroxyflavone, a flavonoid isolated from Glycyrrhiza uralensis, is an eotaxin/CCL11 inhibitor. | ||
| M10148 | Juglone | Anti-infection |
| 5-Hydroxy-1,4-naphthalenedione | ||
| Juglone is a natural naphthoquinone found in the black walnut (Juglans regia) shows antimicrobial activity. The compound is unstable in solution and is recommended to be prepared and used immediately. | ||
| M10578 | Flavone | Metabolite/Endogenous Metabolite |
| 2-Phenyl-4-chromone | ||
| Flavone is an endogenous metabolite. | ||
| M10935 | Tetrahydroxyquinone | ROS |
| Tetrahydroxy-1,4-benzoquinone | ||
| Tetrahydroxyquinone (Tetrahydroxy-1,4-benzoquinone), an anti-cataract agent, is a benzoquinone with redox activity. Tetrahydroxyquinone can participate in the redox cycle with hemiquinone radicals, leading to reactive oxygen species (ROS) formation. | ||
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