About 30 results found for searched term "4-ONE" (0.054 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3052 | TCID | Deubiquitinase |
| 4,5,6,7-Tetrachloroindan-1,3-dione | ||
| TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1. | ||
| M3409 | Formestane | Others |
| 4-hydroxyandrostenedione | ||
| Formestane is a second generation selective aromatase inhibitor with an IC50 of 80 nM. | ||
| M3774 | Kenpaullone | CDK |
| NSC-664704, 9-Bromopaullone, 9-Bromo-7 | ||
| Kenpaullone is potent inhibitor of CDK1/cyclin B and GSK-3β with IC50 values of 0.4 and 0.23 μM respectively. | ||
| M4008 | Liquiritigenin | Estrogen Receptor |
| 4',7-Dihydroxyflavanone | ||
| Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC50 of 36.5 nM for activation of the ERE tk-Luc. | ||
| M4540 | Scutellarein | Src-bcr-Abl |
| 6-Hydroxyapigenin; 4',5,6,7-Tetrahydroxyflavone | ||
| Scutellarein is a natural flavonoid with anti-inflammatory effects. | ||
| M4584 | Acacetin | Potassium Channel |
| 5,7-Dihydroxy-4'-methoxyflavone | ||
| Acacetin is a flavonoid compound that has been shown to have anti-cancer, anti-mutagenic, anti-inflammatory and anti-peroxidative effects. | ||
| M5002 | 4'-Chloropropiophenone | Others |
| 4-pyridazinecarboxamides and esters as interleukin-1beta converting enzyme inhibitors . | ||
| M5359 | 2,2′-Dihydroxy-4-methoxybenzophenone | Others |
| Benzophenone-8; UV-24 | ||
| Dioxybenzone is an organic compound used in sunscreen to block UVB and short-wave UVA (ultraviolet) rays. | ||
| M5370 | 5,5-Dimethyloxazolidine-2,4-dione | Metabolite/Endogenous Metabolite |
| Dimethadione, Dimethyloxazolidinedione, Dimethadion | ||
| Dimethadione is an anticonvulsant that is the active metabolite of trimethadione. | ||
| M5479 | Carsalam | Others |
| Carbonylsalicylamide; 2H-1,3-Benzoxazine-2,4(3H)-dione | ||
| Carsalam (Carbonylsalicylamide) is a non-steroidal anti-inflammatory compound. | ||
| M5730 | L-Cycloserine | GABA Receptor |
| (S)-4-Amino-3-isoxazolidone; (S)-Cycloserine | ||
| L-cycloserine irreversibly inhibit GABA pyridoxal 5′-phosphate-dependent aminitransferase in E. coli, as well in the brains of various animals in a time-dependent manner, results in increased levels of gamma-aminobutyric acid (GABA), which is an inhibitory neurotransmitter in vivo. | ||
| M5902 | Progesterone | Animal Modeling |
| Pregn-4-ene-3,20-dione | ||
| Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor. It can be used to construct a model of melasma as well as a model of fibrocystic hyperplasia of the breast. | ||
| M5907 | Propyphenazone | COX |
| 4-Isopropylantipyrine; Isopropylphenazone | ||
| Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors. | ||
| M6038 | Trimethadione | Calcium Channel |
| 3,5,5,-Trimethyloxazolidine-2,4-dione | ||
| Trimethadione is an oxazolidinedione anticonvulsant; commonly used to treat epileptic conditions. | ||
| M6340 | 3PO | PFKFB3 |
| 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one | ||
| 3PO is a novel small-molecule inhibitor of the PFKFB3 isozyme, attenuates the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines with IC50 of 1.4-24 μM. | ||
| M6451 | Apigenin | Cytochrome P450 (e.g. CYP17) |
| 4',5,7-Trihydroxyflavone; Apigenine; Apigenol; C.I. Natural Yellow 1 | ||
| Apigenin is a competitive CYP2C9 inhibitor with a Ki of 2 μM. | ||
| M6826 | INCA-6 | NFAT |
| INCA6; Triptycene-1,4-quinone | ||
| INCA-6 is a inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT). | ||
| M7630 | Butein | PDE |
| 2’,3,4,4’-tetrahydroxy Chalcone | ||
| Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4. Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Butein is a SIRT1 activator. | ||
| M8027 | Brexanolone | GABA Receptor |
| Allopregnanolone; 3α,5α-THP; SAGE-547; 5α-Pregnan-3α-ol-20-one | ||
| Brexanolone (Allopregnanolone) is a positive allosteric modulator of GABAA chloride channel. | ||
| M8392 | Tirapazamine | Apoptosis |
| SR259075; SR4233; Win59075; SML 0552; Tirazone; TPZ | ||
| Tirapazamine (TPZ，SR-4233, WIN 59075) is the first hypoxia-activated prodrug. Tirapazamine kills hypoxic cells by inducing chromosome aberrations and DNA double-strand breaks. Tirapazamine induced cell cycle arrest and apoptosis, and down-regulated HIF-1α, CA-IX and VEGF expression. | ||
| M8806 | 6, 2′, 4′-trimethoxyflavone | Others |
| 6, 2′, 4′-trimethoxyflavone is a selective aryl hydrocarbon receptor (AHR) antagonist with no partial agonist activity. | ||
| M9051 | FCCP | Mitochondrial Related |
| Carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone | ||
| FCCP is a mitochondrial uncoupling agent and an oxidative phosphorylation (OXPHOS) inhibitor. FCCP is often used as an apoptosis inducer. | ||
| M9310 | 4-Methylumbelliferone | Others |
| Hymecromone, 4-MU | ||
| 4-methylumbelliferone is an inhibitor of hyaluronic acid (HA) synthesis, and 4Mu treatment leads to a 50% reduction in CD47mRNA levels with an IC50 value of 0.4mm in mouse models of liver cancer. | ||
| M9828 | 2-D08 | E1/E2/E3 Enzyme |
| 2D08; 2',3',4'-trihydroxyflavone | ||
| 2-D08 is a cell permeable, mechanistically unique inhibitor of protein SUMOylation. 2-D08 also inhibits Axl with an IC50 of 0.49 nM. | ||
| M9942 | Pratensein | Others |
| 5,7,3'-Trihydroxy-4'-methoxyisoflavone | ||
| Pratensein | ||
| M9944 | 7,4'-Dihydroxyflavone | CCR |
| 7,4'-Dihydroxyflavone, a flavonoid isolated from Glycyrrhiza uralensis, is an eotaxin/CCL11 inhibitor. | ||
| M10148 | Juglone | Anti-infection |
| 5-Hydroxy-1,4-naphthalenedione | ||
| Juglone is a natural naphthoquinone found in the black walnut (Juglans regia) shows antimicrobial activity. The compound is unstable in solution and is recommended to be prepared and used immediately. | ||
| M10578 | Flavone | Metabolite/Endogenous Metabolite |
| 2-Phenyl-4-chromone | ||
| Flavone is an endogenous metabolite. | ||
| M10935 | Tetrahydroxyquinone | ROS |
| Tetrahydroxy-1,4-benzoquinone | ||
| Tetrahydroxyquinone (Tetrahydroxy-1,4-benzoquinone), an anti-cataract agent, is a benzoquinone with redox activity. Tetrahydroxyquinone can participate in the redox cycle with hemiquinone radicals, leading to reactive oxygen species (ROS) formation. | ||
| M11075 | Scutellarein tetramethyl ether | Antibiotic |
| 4',5,6,7-Tetramethoxyflavone | ||
| Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) is a bioactive ingredient found in Siamese grass extract. Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) exerts anti-inflammatory activity through the NF-κB pathway. Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) modulates bacterial resistance through outflow pump inhibition. | ||
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