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2-D08 is a cell permeable, mechanistically unique inhibitor of protein SUMOylation. 2-D08 inhibits sumoylation by preventing transfer of SUMO from the UBC9-SUMO thioester to the substrate. 2-D08 is also an inhibitor of Axl with IC50 of 0.49 nM. 2-D08 decreases the ratio of p-Axl to t-Axl in a dose-dependent manner.
| Molecular Weight | 270.24 |
| Formula | C15H10O5 |
| CAS Number | 144707-18-6 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage | 2-8°C, protect from light, sealed |
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