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LS-102 is a selective E3 ubiquitin ligase synoviolin (Syvn1) inhibitor. LS-102 inhibits the autoubiquitination of synoviolin with an IC50 of 35 μM.
LS-102 (1.3-4 mg/kg; i.p.; daily for 4 weeks) reduced the clinical severity scores in 7-week-old DBA/1 male mice (CIA model).
| Molecular Weight | 452.60 |
| Formula | C24H36N8O |
| CAS Number | 1456891-34-1 |
| Solubility (25°C) | DMSO 75 mg/mL |
| Storage | -20°C, protect from light, sealed |
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