| Cat.No. | Name | Information |
|---|---|---|
| M2969 | PYR-41 | PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2. |
| M31238 | M435-1279 | M435-1279 is a UBE2T inhibitor. M435-1279 inhibits the Wnt/β-catenin signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1. |
| M14330 | TAK-243 | TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. |
| M14326 | Avadomide | Avadomide (CC 122) is an orally effective cereblon modulator. avadomide modulates cereblon E3 ligase activity and induces apoptosis in diffuse large B-cell lymphoma (DLBCL) cells. Avadomide has antitumor and immunomodulatory activities. CC-122 is more potent in degrading IKZF1 and IKZF3 than lenalidomide and has broader and enhanced antiproliferative activity in ABC- and GCB-DLBCL cell lines. |
| M14325 | BI8622 | BI8622 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 3.1 μM. |
| M11295 | Mezigdomide (CC-92480) | Mezigdomide (CC-92480) is a novel protein reducing agent and cereblon E3 ligase modulator (CELMoD). Mezigdomide has a strong affinity with Cereblon and has anti-myeloma activity. |
| M9828 | 2-D08 | 2-D08 is a cell permeable, mechanistically unique inhibitor of protein SUMOylation. |
| M9634 | TAK-981 | TAK-981 is a first-in-class SUMO-activating enzyme inhibitor with superior immune activation and antitumor activity. |
| M8419 | PRT4165 | PRT4165 is a potent inhibitor of PRC1 (polycomb-repressive complex 1)-mediated histone H2A ubiquitylation in vivo and in vitro. |
| M6791 | Heclin | Heclin is a hECT E3 ubiquitin ligase inhibitor. |
| M6750 | Ginkgolic Acid | Ginkgolic Acid is a inhibits SUMOylation by binding E1. |
| M4846 | CC0651 | CC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme and inhibited the ubiquitination of p27Kip1 with IC50 value of 1.72 μM. |
| M2892 | NSC697923 | NSC697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A. |
| M30020 | EN219 | EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC50 of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination. |
| M29907 | RNF5 inhibitor inh-02 | RNF5 inhibitor inh-02 is a potent inhibitor of E3 ubiquitin ligase RNF5/RMA1. RNF5 inhibitor inh-02 leads to significant F508del-CFTR rescue (EC50=2.2 uM) in bronchial epithelial cells homozygous for the F508del mutation. RNF5 inhibitor inh-02 can be used for cystic fibrosis research. |
| M29592 | RB-3 | RB-3, a PRC1 inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM. |
| M29433 | WS-383 | WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2. |
| M29432 | WS-383 free base | WS-383 free base is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 free base inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2. |
| M29429 | DI-1859 | DI-1859 is a potent, selective and covalent inhibitor of DCN1. DI-1859 inhibits neddylation of cullin 3 in cells at low nanomolar concentrations. DI-1859 induces a robust increase of NRF2 protein, a CRL3 substrate, in mouse liver and effectively protects mice from acetaminophen-induced liver damage. |
| M29426 | DI-591 | DI-591 is a potent, high-affinity and cell-permeable inhibitor of the DCN1-UBC12 interaction. DI-591 binds to DCN1 and DCN2 with Ki values of 12 nM and 10.4 nM, respectively and has no appreciable binding to DCN3, DCN4, and DCN5 proteins. DI-591 selectively inhibits neddylation of cullin 3 but has no or minimal effect on neddylation of other cullin family members. |
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