| Cat.No. | Name | Information |
|---|---|---|
| M2969 | PYR-41 | PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2. |
| M58162 | LS-102 | LS-102 is a selective E3 ubiquitin ligase synoviolin (Syvn1) inhibitor. LS-102 inhibits the autoubiquitination of synoviolin with an IC50 of 35 μM. |
| M54750 | SENP1-IN-1 | SENP1-IN-1 is a specific deSUMOylation protease 1 (SENP1) inhibitor. SENP1-IN-1 can be used for tumor radiosensitivity enhancement. |
| M31238 | M435-1279 | M435-1279 is a UBE2T inhibitor. M435-1279 inhibits the Wnt/β-catenin signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1. |
| M25545 | Brigimadlin | Brigimadlin (BI 907828) is an E3 ubiquitin-protein ligase MDM-2 inhibitor. Brigimadlin serves as an antineoplastic agent. |
| M20714 | NAcM-OPT | NAcM-OPT is a specific, reversible and orally bioavailable inhibitor of cullin neddylation 1 (DCN1) that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM. |
| M14331 | TZ9 | TZ9 is a novel inhibitor of Rad6 ubiquitin conjugating enzyme(E2 enzyme); inhibits MDA-MB-231 cell proliferation with IC50 of ~6 uM. |
| M14330 | TAK-243 | TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. |
| M14326 | Avadomide | Avadomide (CC 122) is an orally effective cereblon modulator. avadomide modulates cereblon E3 ligase activity and induces apoptosis in diffuse large B-cell lymphoma (DLBCL) cells. Avadomide has antitumor and immunomodulatory activities. CC-122 is more potent in degrading IKZF1 and IKZF3 than lenalidomide and has broader and enhanced antiproliferative activity in ABC- and GCB-DLBCL cell lines. |
| M14325 | BI8622 | BI8622 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 3.1 μM. |
| M11295 | Mezigdomide (CC-92480) | Mezigdomide (CC-92480) is a novel protein reducing agent and cereblon E3 ligase modulator (CELMoD). Mezigdomide has a strong affinity with Cereblon and has anti-myeloma activity. |
| M9828 | 2-D08 | 2-D08 is a cell permeable, mechanistically unique inhibitor of protein SUMOylation. 2-D08 also inhibits Axl with an IC50 of 0.49 nM. |
| M9634 | Subasumstat | Subasumstat (TAK-981) is a first-in-class SUMO-activating enzyme inhibitor with superior immune activation and antitumor activity. |
| M8419 | PRT4165 | PRT4165 is a potent inhibitor of PRC1 (polycomb-repressive complex 1)-mediated histone H2A ubiquitylation in vivo and in vitro. |
| M6791 | Heclin | Heclin is a hECT E3 ubiquitin ligase inhibitor. |
| M6750 | Ginkgolic Acid | Ginkgolic Acid is a inhibits SUMOylation by binding E1. |
| M6072 | Iberdomide | Iberdomide (CC-220) is an orally effective cereblon (CRBN) E3 ligase modulator (CELMoD) with an IC50 for cereblon binding affinity of approximately 150 nM. Iberdomide (CC-220) binds CRBN with higher affinity than lenalidomide and pomalidomide and has enhanced degradation of IKZF1 and IKZF3 with enhanced degradation. |
| M4846 | CC0651 | CC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme and inhibited the ubiquitination of p27Kip1 with IC50 value of 1.72 μM. |
| M2892 | NSC697923 | NSC697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A. |
| M54804 | NX-1607 | NX-1607 is an oral, small molecule inhibitor of casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) that has been shown to enhance antigen recall, reduce T cell exhaustion and increase cytokine production upon T cell receptor stimulation, overcoming suppressive signals from the tumor microenvironment (TME). |
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