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Subasumstat (TAK-981) is a potent and selective SUMOylation enzymatic cascade inhibitor with potential immune-activating and antineoplastic activities. Subasumstat (TAK-981) targets and covalently binds to the small ubiquitin-like modifier (SUMO; small ubiquitin-related modifier) protein, which prevents the transfer of SUMO from the SUMO-activating enzyme (SAE) to SUMO-conjugating enzyme UBC9. Subasumstat (TAK-981) is able to increase the production of type 1 IFN, thereby increasing type 1 IFN-mediated signaling, activating innate effector cells and enhancing the antitumor innate immune responses.
| Molecular Weight | 578.10 |
| Formula | C25H28ClN5O5S2 |
| CAS Number | 1858276-04-6 |
| Solubility (25°C) | DMSO ≥ 18 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Li Du, et al. SUMOylation inhibition enhances dexamethasone sensitivity in multiple myeloma
[3] Antti Kukkula, et al. Therapeutic Potential of Targeting the SUMO Pathway in Cancer
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