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NX-1607 is an oral, small molecule inhibitor of CBL-B with an IC50 of < 1 nM, it has been shown to enhance antigen recall, reduce T cell exhaustion and increase cytokine production upon T cell receptor stimulation, overcoming suppressive signals from the tumor microenvironment (TME). NX-1607 has demonstrated anti-tumor activity and long-term survival in murine models as both a single agent and in combination with programmed cell death protein-1 (PD-1) antibodies. Further, NX-1607 elicits dose-dependent increases in cytokine secretion and proliferation in T-cell receptor-stimulated primary human T cells with enhanced tumor antigen-specific T-cell and NK cell anti-tumor responses.
| Molecular Weight | 537.62 |
| Formula | C30H34F3N5O |
| CAS Number | 2573775-59-2 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage | 4°C, dry, sealed |
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