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Apigenin

Cat. No. M6451
Apigenin Structure
Synonym:

4',5,7-Trihydroxyflavone; Apigenine; Apigenol; C.I. Natural Yellow 1

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
50mg USD 60  USD60 In stock
100mg USD 110  USD110 In stock
500mg USD 265  USD265 In stock
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Quality Control
Biological Activity

Apigenin is a protein kinase inhibitor. Suppresses tumor-promoting effects of TPA and exhibits antiproliferative activity in human breast cancer cells (IC50 values are 59.44 and 31.15 μM at 24 and 72 hrs respectively). Activates both the intrinsic and extrinsic apoptotic pathways and displays anti-inflammatory, hypotensive, antispasmodic and antioxidant properties in vivo.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 270.2
Formula C15H10O5
CAS Number 520-36-5
Purity >98%
Solubility DMSO ≥ 10 mg/mL
Storage at -20°C
References

[1] Veale, et al. Part 1 Bioorg Med Chem Lett. The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists.

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Keywords: Apigenin, 4',5,7-Trihydroxyflavone; Apigenine; Apigenol; C.I. Natural Yellow 1 supplier, Cytochrome P450 (e.g. CYP17), inhibitors

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