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Juglone is a natural naphthoquinone found in the black walnut (Juglans regia) shows antimicrobial activity. Juglone irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human Pin1, yeast Ess1/Ptf1, and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I, II, and III (IC50s = 2-7 µM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through Pin1-independent mechanisms.
The compound is unstable in solution and is recommended to be prepared and used immediately.
| Molecular Weight | 174.15 |
| Formula | C10H6O3 |
| CAS Number | 481-39-0 |
| Solubility (25°C) | DMSO 10 mg/mL Ethanol 5 mg/mL |
| Storage | 2-8°C, protect from light, sealed |
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