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TNF-alpha TNF-alpha

Inhibitors

Cat.No.  Name Information
M1962 Lenalidomide Lenalidomide is a thalidomide analog known to display TNF-α secretion inhibition and possesses immunomodulatory properties.
M6224 Etanercept Etanercept is a dimer fusion protein that binds tumor necrosis factor (TNF) as a TNF inhibitor. Etanercept competitively inhibits the binding of TNF-α and TNF-β to TNF receptors on the cell surface, rendering tumor necrosis factor biologically inactive.
M4974 GW4869 2HCl GW4869 (GW69A, GW554869A) is a noncompetitive inhibitor of neutral Smase (spspingolipase) with IC50 of 1 μM.
M2225 Thalidomide Thalidomide is a sedative and immunomodulator used to study the symptoms of many cancers. Thalidomide inhibits E3 ubiquitin ligase, a CrBN-DDB1-Cul4A complex.
M13561 C25-140 C25-140, a first-in-class, orally active, and fairly selective TRAF6-Ubc13 inhibitor, directly binds to TRAF6, and blocks the interaction of TRAF6 with Ubc13. C25-140 lowers TRAF6 activity, reduces NF-κB activation, and combats autoimmunity.
M13560 AX-024 AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM.
M13559 1,4-Dicaffeoylquinic acid 1,4-Dicaffeoylquinic acid (1,4-DCQA) is a phenylpropanoid from Xanthii fructus, inhibits LPS-stimulated TNF-α production.
M11009 UCB-9260 UCB-9260 is an orally active small molecule that inhibits tumor necrosis factor (TNF) signaling through an asymmetrical form of a stable trimer. UCB-9260 is more selective to tumor necrosis factor than other superfamily members and binds to tumor necrosis factor Kd The value is 13 nM.
M10667 UTL-5g UTL-5g is a novel potential chemoprotective agent, TNF-α inhibitor that reduces cisplatin-induced side effects including nephrotoxicity, hepatotoxicity and hematotoxicity.
M10643 Benpyrine racemate Benpyrine racemate ((Rac)-Benpyrine) is a racemate of Benpyrine, Benpyrine racemate ((Rac)-Benpyrine) is a potent and orally active TNF-α inhibitor and has the potential for TNF-α mediated inflammatory and autoimmune disease research.
M10468 N-Formyl-Met-Leu-Phe N-Formyl-Met-Leu-Phe (fMLP) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR), which can inhibit TNF-alpha secretion.
M10324 Cynaropicrin Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release and the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.
M9710 Roquinimex Roquinimex (LS2616; FCF89) is a quinoline-3-carboxamide with potential antineoplastic activity, which increases NK cell activity and macrophage cytotoxicity.
M8516 R-7050 R-7050 is a cell-permeable TNF-α receptor antagonist that blocks TNF-α-induced binding of TNF-αRI with TNFαR-associated death domain protein and receptor interacting protein 1, blocking internalization of the TNFα-TNFαR complex.
M6224 Etanercept Etanercept is a dimer fusion protein that binds tumor necrosis factor (TNF) as a TNF inhibitor. Etanercept competitively inhibits the binding of TNF-α and TNF-β to TNF receptors on the cell surface, rendering tumor necrosis factor biologically inactive.
M6222 Adalimumab Adalimumab is the first fully human, recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha, MW: 144.19 KD.
M5732 Lenalidomide hemihydrate Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.
M5272 Bioymifi Bioymifi, a small-molecule death receptor 5 (DR5) agonist, binds to the extracellular domain(ECD) of DR5 with a Kd of 1.2 μM but showed little binding affinity to the DR4 ECD. It induces DR5 clustering and aggregation, leading to apoptosis.
M4974 GW4869 2HCl GW4869 (GW69A, GW554869A) is a noncompetitive inhibitor of neutral Smase (spspingolipase) with IC50 of 1 μM.
M4740 Corilagin Corilagin is an inhibitor of TNF-α, discovered in many medicinal plants such as Phyllanthus speices etc., has multiple activities including anti-oxidative, anti-inflammatory, anti-apoptotic, hepatoprotective and others.
M4737 Geraniin Geraniin is a TNF-α releasing inhibitor with an IC50 of 43 μM, it has numerous activities including anticancer, anti-inflammatory, and anti-hyperglycemic activities.
M4378 Forsythoside-B Forsythoside-B inhibits TNF-alpha, IL-6, IκB and modulate NF-κB.
M2225 Thalidomide Thalidomide is a sedative and immunomodulator used to study the symptoms of many cancers. Thalidomide inhibits E3 ubiquitin ligase, a CrBN-DDB1-Cul4A complex.
M1962 Lenalidomide Lenalidomide is a thalidomide analog known to display TNF-α secretion inhibition and possesses immunomodulatory properties.



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