|M10324||Cynaropicrin||Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release and the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.|
|M9710||Roquinimex||Roquinimex (LS2616; FCF89) is a quinoline-3-carboxamide with potential antineoplastic activity, which increases NK cell activity and macrophage cytotoxicity.|
|M6224||Etanercept||Etanercept is a dimeric fusion protein consisting of two ligand-binding domains of human p75 tumor necrosis factor receptor and the human IgG1 Fc portion.|
|M6222||Adalimumab||Adalimumab is the first fully human, recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha, MW: 144.19 KD.|
|M5732||Lenalidomide hemihydrate||Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.|
|M5385||Acetylcysteine (NAC)||Acetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor.|
|M5272||Bioymifi||Bioymifi, a small-molecule death receptor 5 (DR5) agonist, binds to the extracellular domain(ECD) of DR5 with a Kd of 1.2 μM but showed little binding affinity to the DR4 ECD. It induces DR5 clustering and aggregation, leading to apoptosis.|
|M5209||GSK481||GSK481 is a highly potent and monoselective Receptor Interacting Protein 1 kinase inhibitor.|
|M4974||GW4869 2HCl||GW4869 (GW69A, GW554869A) is a noncompetitive inhibitor of neutral Smase (spspingolipase) with IC50 of 1 μM.|
|M4740||Corilagin||Corilagin is an inhibitor of TNF-α, discovered in many medicinal plants such as Phyllanthus speices etc., has multiple activities including anti-oxidative, anti-inflammatory, anti-apoptotic, hepatoprotective and others.|
|M4378||Forsythoside-B||Forsythoside-B inhibits TNF-alpha, IL-6, IκB and modulate NF-κB.|
|M2225||Thalidomide||Thalidomide is a selective inhibitor of tumor necrosis factor α (TNF-α) synthesis.|
|M1962||Lenalidomide||Lenalidomide is a thalidomide analog known to display TNF-α secretion inhibition and possesses immunomodulatory properties.|
|M1545||Infliximab||Infliximab is a purified, recombinant DNA-derived chimeric human-mouse IgG monoclonal antibody that works against tumor necrosis factor alpha (TNF-α) and is used to treat autoimmune diseases.|
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