All AbMole products are for research use only, cannot be used for human consumption.
C25-140, a first-in-class, orally active, and fairly selective TRAF6-Ubc13 inhibitor, directly binds to TRAF6, and blocks the interaction of TRAF6 with Ubc13. C25-140 lowers TRAF6 activity, reduces NF-κB activation, and combats autoimmunity.
Genes & Diseases. 2026 Mar 02; .
TRAF6 inhibition suppresses vasculogenic mimicry in oral squamous cell carcinoma via targeting IL-33/ST2L-induced EMT
C25-140 purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | H9C2 cells |
| Preparation method | Inhibition of TRAF6 attenuated LPS-mediated myocardial injury. The H9C2 cardiomyocytes were pretreated with C25-140 (5 μM, an inhibitor of TRAF6) for 2 h and then treated with LPS (10 μg/ml) and Deh (10 μg/ml) for 24 h. |
| Concentrations | 2 h |
| Incubation time | 5 μM |
| Animal Experiment | |
|---|---|
| Animal models | Male Kunming mouse |
| Formulation | Not mentioned |
| Dosages | 10 mg/kg |
| Administration | i.p. |
| Molecular Weight | 457.57 |
| Formula | C26H31N7O |
| CAS Number | 1358099-18-9 |
| Solubility (25°C) | DMSO 62.5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related TNF Receptor Products |
|---|
| Atrosab
Atrosab is a humanized IgG1 antagonistic anti-TNFR1 antibody. Atrosab inhibits TNF-mediated Apoptosis induction and IL-6 and IL-8 production. Atrosab reduces neurological deficits. |
| Mesaconitine
Mesaconitine is the main active ingredient of Aconitum and has many pharmaceutical effects. |
| Hypaconitine
Hypaconitine is a highly toxic natural active ingredient isolated from aconitum species, which is widely used to study rheumatism. |
| Shikonin
Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844) is an effective and specific inhibitor of Pyruvate kinase M2 (PKM2). Shikonin is the main ingredient of Lithosia, a Chinese herb with a variety of biological activities. Shikonin acts as an anti-inflammatory by inhibiting tumor necrosis factor-α (TNF-α), Proteasome can inhibit the activation of nuclear factor-κB (NF-κB) signaling pathway. |
| Forsythoside B
Forsythoside B inhibits TNF-alpha, IL-6, IκB and modulate NF-κB. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
