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C25-140

Cat. No. M13561

All AbMole products are for research use only, cannot be used for human consumption.

C25-140 Structure
Size Price Availability Quantity
1mg USD 75  USD75 In stock
5mg USD 145  USD145 In stock
10mg USD 230  USD230 In stock
25mg USD 400  USD400 In stock
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Quality Control & Documentation
Biological Activity

C25-140, a first-in-class, orally active, and fairly selective TRAF6-Ubc13 inhibitor, directly binds to TRAF6, and blocks the interaction of TRAF6 with Ubc13. C25-140 lowers TRAF6 activity, reduces NF-κB activation, and combats autoimmunity.

Chemical Information
Molecular Weight 457.57
Formula C26H31N7O
CAS Number 1358099-18-9
Solubility (25°C) DMSO 62.5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yadong Li, et al. Front Pharmacol. Dehydrocorydaline Protects Against Sepsis-Induced Myocardial Injury Through Modulating the TRAF6/NF-κB Pathway

[2] Qi Zeng, et al. Int Immunopharmacol. TLR4/TRAF6/NOX2 signaling pathway is involved in ventilation-induced lung injury via endoplasmic reticulum stress in murine model

[3] Jara K Brenke, et al. J Biol Chem. Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity

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Keywords: C25-140 supplier, TNF Receptor, inhibitors, activators

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