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Hypaconitine

Cat. No. M4022

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Hypaconitine Structure
Size Price Availability Quantity
20mg USD 180  USD180 In stock
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Quality Control & Documentation
Biological Activity

Hypaconitine is a highly toxic natural active ingredient isolated from aconitum species, which is widely used to study rheumatism.

Chemical Information
Molecular Weight 615.72
Formula C33H45NO10
CAS Number 6900-87-4
Form Solid
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Shu-Shong Hsu, et al. Mechanism of action of a diterpene alkaloid hypaconitine on cytotoxicity and inhibitory effect of BAPTA-AM in HCN-2 neuronal cells

[2] Jiali Gao, et al. The mechanism underlying hypaconitine-mediated alleviation of pancreatitis-associated lung injury through up-regulating aquaporin-1/TNF-α

[3] Yanke Lin, et al. Circadian Cyp3a11 metabolism contributes to chronotoxicity of hypaconitine in mice

[4] Shuilin Xie, et al. Hypaconitine-induced QT prolongation mediated through inhibition of KCNH2 (hERG) potassium channels in conscious dogs

[5] Thomas Y K Chan. Aconite poisoning

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